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Gene Review

MMP16  -  matrix metallopeptidase 16 (membrane...

Homo sapiens

Synonyms: C8orf57, DKFZp761D112, MMP-16, MMP-X2, MMPX2, ...
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Disease relevance of MMP16


High impact information on MMP16


Biological context of MMP16


Anatomical context of MMP16


Associations of MMP16 with chemical compounds

  • The association between MT3-MMP and MCSP was largely disrupted by removing chondroitin sulfate glycosaminoglycan (CS) from the cell surface, suggesting CS could mediate the association between the two cell surface core proteins [1].
  • There was a general higher expression of all MT-MMPs except for MT3-MMP in the androgen-insensitive cells DU 145 and PC-3 compared with that in the androgen-sensitive LNCaP cells [15].
  • Effect of Losartan on the mRNA Expressions of MT3-MMP and TIMP-2 in Diabetic Kidneys [16].

Enzymatic interactions of MMP16

  • The recombinant APP protein was cleaved by MT3-MMP in vitro at the A(463)-M(464), N(579)-M(580), H(622)-S(623), and H(685)-Q(686) peptide bonds, which included a cleavage site within the amyloid beta peptide region known to produce a C-terminal fragment [17].

Regulatory relationships of MMP16

  • The results indicate that MT3-MMP possesses the potential to promote melanoma invasion and proteolysis and that the formation of a complex between MT3-MMP and MCSP may be a crucial step in activating these processes [1].
  • Shedding of syndecan-1 was also induced by MT3-MMP but not by other MT-MMPs [18].

Other interactions of MMP16


Analytical, diagnostic and therapeutic context of MMP16


  1. Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. Iida, J., Pei, D., Kang, T., Simpson, M.A., Herlyn, M., Furcht, L.T., McCarthy, J.B. J. Biol. Chem. (2001) [Pubmed]
  2. Expression of messenger RNAs for membrane-type 1, 2, and 3 matrix metalloproteinases in human renal cell carcinomas. Kitagawa, Y., Kunimi, K., Uchibayashi, T., Sato, H., Namiki, M. J. Urol. (1999) [Pubmed]
  3. Membrane type-matrix metalloproteinases in idiopathic pulmonary fibrosis. García-Alvarez, J., Ramirez, R., Sampieri, C.L., Nuttall, R.K., Edwards, D.R., Selman, M., Pardo, A. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders. (2006) [Pubmed]
  4. Expression of mRNA for membrane-type 1, 2, and 3 matrix metalloproteinases in human laryngeal cancer. Sun, Y.N., Li, Y. Chin. Med. Sci. J. (2004) [Pubmed]
  5. beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer. Lowy, A.M., Clements, W.M., Bishop, J., Kong, L., Bonney, T., Sisco, K., Aronow, B., Fenoglio-Preiser, C., Groden, J. Cancer Res. (2006) [Pubmed]
  6. Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. Nakada, M., Yamada, A., Takino, T., Miyamori, H., Takahashi, T., Yamashita, J., Sato, H. Cancer Res. (2001) [Pubmed]
  7. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas. Ueno, H., Nakamura, H., Inoue, M., Imai, K., Noguchi, M., Sato, H., Seiki, M., Okada, Y. Cancer Res. (1997) [Pubmed]
  8. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. Mattei, M.G., Roeckel, N., Olsen, B.R., Apte, S.S. Genomics (1997) [Pubmed]
  9. Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features. Lang, R., Braun, M., Sounni, N.E., Noel, A., Frankenne, F., Foidart, J.M., Bode, W., Maskos, K. J. Mol. Biol. (2004) [Pubmed]
  10. Elevated expression of membrane-type 1 and 3 matrix metalloproteinases in rat vascular smooth muscle cells activated by arterial injury. Shofuda, K., Nagashima, Y., Kawahara, K., Yasumitsu, H., Miki, K., Miyazaki, K. Lab. Invest. (1998) [Pubmed]
  11. Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase. Shimada, T., Nakamura, H., Ohuchi, E., Fujii, Y., Murakami, Y., Sato, H., Seiki, M., Okada, Y. Eur. J. Biochem. (1999) [Pubmed]
  12. Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Pap, T., Shigeyama, Y., Kuchen, S., Fernihough, J.K., Simmen, B., Gay, R.E., Billingham, M., Gay, S. Arthritis Rheum. (2000) [Pubmed]
  13. Involvement of membrane-type matrix metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial cells: role of MT3-MMP. Plaisier, M., Kapiteijn, K., Koolwijk, P., Fijten, C., Hanemaaijer, R., Grimbergen, J.M., Mulder-Stapel, A., Quax, P.H., Helmerhorst, F.M., van Hinsbergh, V.W. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  14. Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells. Shofuda, K., Moriyama, K., Nishihashi, A., Higashi, S., Mizushima, H., Yasumitsu, H., Miki, K., Sato, H., Seiki, M., Miyazaki, K. J. Biochem. (1998) [Pubmed]
  15. mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue. Jung, M., Römer, A., Keyszer, G., Lein, M., Kristiansen, G., Schnorr, D., Loening, S.A., Jung, K. Prostate (2003) [Pubmed]
  16. Effect of Losartan on the mRNA Expressions of MT3-MMP and TIMP-2 in Diabetic Kidneys. Ding, H.L., Xu, M.T., Guo, Y., Chen, L., Zhang, S.L., Li, F., Fu, Z.Z. The review of diabetic studies : RDS (2005) [Pubmed]
  17. Cleavage of Amyloid-{beta} Precursor Protein (APP) by Membrane-Type Matrix Metalloproteinases. Ahmad, M., Takino, T., Miyamori, H., Yoshizaki, T., Furukawa, M., Sato, H. J. Biochem. (2006) [Pubmed]
  18. Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. Endo, K., Takino, T., Miyamori, H., Kinsen, H., Yoshizaki, T., Furukawa, M., Sato, H. J. Biol. Chem. (2003) [Pubmed]
  19. A cryptic deletion of 2q35 including part of the PAX3 gene detected by breakpoint mapping in a child with autism and a de novo 2;8 translocation. Borg, I., Squire, M., Menzel, C., Stout, K., Morgan, D., Willatt, L., O'Brien, P.C., Ferguson-Smith, M.A., Ropers, H.H., Tommerup, N., Kalscheuer, V.M., Sargan, D.R. J. Med. Genet. (2002) [Pubmed]
  20. Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues. Yoshiyama, Y., Sato, H., Seiki, M., Shinagawa, A., Takahashi, M., Yamada, T. Acta Neuropathol. (1998) [Pubmed]
  21. Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization. Sato, H., Tanaka, M., Takino, T., Inoue, M., Seiki, M. Genomics (1997) [Pubmed]
  22. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines. Uzui, H., Harpf, A., Liu, M., Doherty, T.M., Shukla, A., Chai, N.N., Tripathi, P.V., Jovinge, S., Wilkin, D.J., Asotra, K., Shah, P.K., Rajavashisth, T.B. Circulation (2002) [Pubmed]
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