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Gene Review

nmr-1  -  Protein NMR-1

Caenorhabditis elegans

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High impact information on nmr-1

  • We also show that a slowly desensitizing variant of a non-NMDA receptor can rescue the nmr-1 mutant phenotype [1].
  • Electrical recordings from the interneuron AVA show that NMDA-dependent currents are selectively disrupted in nmr-1 mutants [1].
  • A null mutant of nmr-1, which encodes a C. elegans NMDA receptor, was completely resistant to the behavioral effects of N(2)O, whereas a non-NMDA receptor-null mutant was normally sensitive [2].
  • Mutation of glr-1, encoding a non-NMDA glutamate receptor subunit, abolished the behavioral effects of xenon; however, mutation of nmr-1, which encodes the pore-forming subunit of an NMDA glutamate receptor previously shown to be required for nitrous oxide action, did not significantly alter xenon response [3].


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