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Gene Review

Nmdar1  -  NMDA receptor 1

Drosophila melanogaster

Synonyms: CG2902, DMNMDAR1, DNMDAR-I, DNmdar, DmelNmdar1, ...
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High impact information on Nmdar1

  • In vertebrates, the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) appears to play a role in neuronal development, synaptic plasticity, memory formation, and pituitary activity [1].
  • Finally, we used the same primers for DNMDAR1 to demonstrate a fragment of putative NMDA receptor in the corpora allata of Diploptera punctata [1].
  • Cockroach corpus allatum (CA) cells, exposed to NMDA in vitro, exhibited elevated cytosolic [Ca(2+)], but not in culture medium nominally free of calcium or containing NMDAR-specific channel blockers: MK-801 and Mg(2+) [1].
  • RESULTS: The Drosophila genome encodes two NMDAR homologs, dNR1 and dNR2 [2].
  • The deduced amino acid sequence of DNMDAR-I displays 46% amino acid identity to the rat NMDAR1 polypeptide and shows significant homology (16-23%) to other vertebrate and invertebrate glutamate receptor proteins [3].

Biological context of Nmdar1


Associations of Nmdar1 with chemical compounds


  1. Insect NMDA receptors mediate juvenile hormone biosynthesis. Chiang, A.S., Lin, W.Y., Liu, H.P., Pszczolkowski, M.A., Fu, T.F., Chiu, S.L., Holbrook, G.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. NMDA receptors mediate olfactory learning and memory in Drosophila. Xia, S., Miyashita, T., Fu, T.F., Lin, W.Y., Wu, C.L., Pyzocha, L., Lin, I.R., Saitoe, M., Tully, T., Chiang, A.S. Curr. Biol. (2005) [Pubmed]
  3. Glutamate receptors of Drosophila melanogaster. Primary structure of a putative NMDA receptor protein expressed in the head of the adult fly. Ultsch, A., Schuster, C.M., Laube, B., Betz, H., Schmitt, B. FEBS Lett. (1993) [Pubmed]
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