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Gene Review

cki-2  -  Protein CKI-2

Caenorhabditis elegans

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High impact information on cki-2

  • This implies that the proper regulation of a cyclin E-Cdk complex by cki-2 is required for the elimination of the centrosome that occurs before or during oogenesis to ensure the assembly of a bipolar spindle in the C. elegans zygote [1].
  • We show that cki-2, a Caenorhabditis elegans cyclin-dependent kinase (Cdk) inhibitor, is required for their appropriate elimination during oogenesis [1].
  • In the absence of cki-2, embryos have supernumerary centrosomes and form multipolar spindles that result in severe aneuploidy after anaphase of the first division [1].
  • In contrast, cki-2 is not capable of significantly rescuing these phenotypes [2].


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