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Gene Review:

cki-2 - Protein CKI-2

Caenorhabditis elegans

Kim, D.Y. et al., Fukuyama, M. et al.

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High impact information on cki-2

This implies that the proper regulation of a cyclin E-Cdk complex by cki-2 is required for the elimination of the centrosome that occurs before or during oogenesis to ensure the assembly of a bipolar spindle in the C. elegans zygote [1].
We show that cki-2, a Caenorhabditis elegans cyclin-dependent kinase (Cdk) inhibitor, is required for their appropriate elimination during oogenesis [1].
In the absence of cki-2, embryos have supernumerary centrosomes and form multipolar spindles that result in severe aneuploidy after anaphase of the first division [1].
In contrast, cki-2 is not capable of significantly rescuing these phenotypes [2].

References

Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans. Kim, D.Y., Roy, R. J. Cell Biol. (2006) [Pubmed]
Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans. Fukuyama, M., Gendreau, S.B., Derry, W.B., Rothman, J.H. Dev. Biol. (2003) [Pubmed]

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