Gene Review:
fzr-1 - Protein FZR-1
Caenorhabditis elegans
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High impact information on fzr-1
- From this screen we have identified fzr-1, a gene that synthetically interacts with lin-35 to produce global defects in cell proliferation control. fzr-1 encodes the C. elegans homolog of Cdh1/Hct1/FZR, a gene product shown in other systems to regulate the APC cyclosome [1].
- We have also uncovered genetic interactions between fzr-1 and a subset of class B SynMuv genes, and between lin-35 and the putative SCF regulator lin-23 [1].
Biological context of fzr-1
- fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen [1].
References
- fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Fay, D.S., Keenan, S., Han, M. Genes Dev. (2002) [Pubmed]
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