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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lin-23  -  Protein LIN-23

Caenorhabditis elegans

 
 
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Disease relevance of lin-23

 

High impact information on lin-23

  • We have also uncovered genetic interactions between fzr-1 and a subset of class B SynMuv genes, and between lin-35 and the putative SCF regulator lin-23 [2].
  • In contrast, lin-23 functions cell autonomously to negatively regulate cell cycle progression, thereby allowing cell cycle exit in response to developmental signals [3].
  • Here we describe the lin-23 gene of Caenorhabditis elegans, which is required to restrain cell proliferation in response to developmental cues [3].
  • This mutant is allelic to lin-23, which codes for an F-box-containing component of an SCF E3 ubiquitin ligase complex that was previously shown to negatively regulate postembryonic cell divisions [4].

References

  1. Restriction of vaccinia virus replication by a ced-3 and ced-4-dependent pathway in Caenorhabditis elegans. Liu, W.H., Lin, Y.L., Wang, J.P., Liou, W., Hou, R.F., Wu, Y.C., Liao, C.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Fay, D.S., Keenan, S., Han, M. Genes Dev. (2002) [Pubmed]
  3. The C. elegans F-box/WD-repeat protein LIN-23 functions to limit cell division during development. Kipreos, E.T., Gohel, S.P., Hedgecock, E.M. Development (2000) [Pubmed]
  4. A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23. Mehta, N., Loria, P.M., Hobert, O. Genetics (2004) [Pubmed]
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