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Gene Review

FZR1  -  fizzy/cell division cycle 20 related 1...

Homo sapiens

Synonyms: CDC20-like protein 1, CDC20C, CDH1, Cdh1/Hct1 homolog, FYR, ...
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Disease relevance of FZR1


High impact information on FZR1

  • The DNA damage-induced mitotic exit delay correlates with the inhibition of Cdh1 activation and the attenuated degradation of cyclin B1 [4].
  • Direct evidence of E-cadherin mutations triggering tumorigenesis has come from the finding of inactivating germline mutations of the gene (CDH1) in hereditary diffuse gastric cancer (HDGC) [5].
  • In this study we investigated the importance of periodic oscillation of the APC-Cdh1 activity for the cell cycle progression in human cells [6].
  • Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis [6].
  • Consequently, failure to inactivate APC-Cdh1 beyond the G(1)/S transition not only inhibited productive cell division but also supported slow but uninterrupted DNA replication, precluding S-phase exit and causing massive overreplication of the genome [6].

Biological context of FZR1


Anatomical context of FZR1


Associations of FZR1 with chemical compounds

  • The effect of rapamycin on the degradation rate of Skp2 expression was examined in cycloheximide-treated cells and in relationship to the anaphase promoting complex/Cdh1 (APC\C) inhibitor Emi1 [13].


  1. Chromoendoscopic surveillance in hereditary diffuse gastric cancer: an alternative to prophylactic gastrectomy? Shaw, D., Blair, V., Framp, A., Harawira, P., McLeod, M., Guilford, P., Parry, S., Charlton, A., Martin, I. Gut (2005) [Pubmed]
  2. High-resolution integrated map encompassing the breast cancer loss of heterozygosity region on human chromosome 16q22.1. Frengen, E., Rocca-Serra, P., Shaposhnikov, S., Taine, L., Thorsen, J., Bepoldin, C., Krekling, M., Lafon, D., Aas, K.K., El Monéim, A.A., Johansen, H., Longy, M., Prydz, H., Dorion-Bonnet, F. Genomics (2000) [Pubmed]
  3. Loss of E-cadherin expression in gastric intestinal metaplasia and later stage p53 altered expression in gastric carcinogenesis. Mingchao, n.u.l.l., Devereux, T.R., Stockton, P., Sun, K., Sills, R.C., Clayton, N., Portier, M., Flake, G. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2001) [Pubmed]
  4. DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Huang, X., Tran, T., Zhang, L., Hatcher, R., Zhang, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Suriano, G., Oliveira, C., Ferreira, P., Machado, J.C., Bordin, M.C., De Wever, O., Bruyneel, E.A., Moguilevsky, N., Grehan, N., Porter, T.R., Richards, F.M., Hruban, R.H., Roviello, F., Huntsman, D., Mareel, M., Carneiro, F., Caldas, C., Seruca, R. Hum. Mol. Genet. (2003) [Pubmed]
  6. Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Sorensen, C.S., Lukas, C., Kramer, E.R., Peters, J.M., Bartek, J., Lukas, J. Mol. Cell. Biol. (2000) [Pubmed]
  7. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Wei, W., Ayad, N.G., Wan, Y., Zhang, G.J., Kirschner, M.W., Kaelin, W.G. Nature (2004) [Pubmed]
  8. Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Graziano, F., Arduini, F., Ruzzo, A., Bearzi, I., Humar, B., More, H., Silva, R., Muretto, P., Guilford, P., Testa, E., Mari, D., Magnani, M., Cascinu, S. Clin. Cancer Res. (2004) [Pubmed]
  9. Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. Moreno-Bueno, G., Hardisson, D., Sarrió, D., Sánchez, C., Cassia, R., Prat, J., Herman, J.G., Esteller, M., Matías-Guiu, X., Palacios, J. J. Pathol. (2003) [Pubmed]
  10. Epithelial-mesenchymal transition in gastric cancer (Review). Katoh, M. Int. J. Oncol. (2005) [Pubmed]
  11. Aberrant E-cadherin staining patterns in invasive mammary carcinoma. Harigopal, M., Shin, S.J., Murray, M.P., Tickoo, S.K., Brogi, E., Rosen, P.P. World journal of surgical oncology [electronic resource]. (2005) [Pubmed]
  12. Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated? Chun, Y.S., Lindor, N.M., Smyrk, T.C., Petersen, B.T., Burgart, L.J., Guilford, P.J., Donohue, J.H. Cancer (2001) [Pubmed]
  13. The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells. Shapira, M., Kakiashvili, E., Rosenberg, T., Hershko, D.D. Breast Cancer Res. (2006) [Pubmed]
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