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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

srw1  -  CDK inhibitor Srw1

Schizosaccharomyces pombe 972h-

 
 
 
 
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High impact information on srw1

  • We also show that ste9/srw1 is negatively regulated by cdc2-dependent protein phosphorylation [1].
  • APC(ste9/srw1) is not necessary for the proteolysis of cdc13 and cig1 that occurs at the metaphase-anaphase transition but it is absolutely required for their degradation in G(1) [1].
  • Therefore, we propose that the main role of APC(ste9/srw1) is to promote degradation of mitotic cyclins when cells need to delay or arrest the cell cycle in G(1) [1].

References

  1. APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation. Blanco, M.A., Sánchez-Díaz, A., de Prada, J.M., Moreno, S. EMBO J. (2000) [Pubmed]
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