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Gene Review

daf-19  -  Protein DAF-19

Caenorhabditis elegans

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High impact information on daf-19

  • We show that this novel protein localizes to basal bodies in mouse and C. elegans, is under the regulatory control of daf-19, and is necessary for the generation of both cilia and flagella [1].
  • Several genes that function in all ciliated sensory neurons have an RFX target site in their promoters and require daf-19 function [2].
  • Reduction of dyf-3Colon, two colonsgfp expression in a daf-19 mutant suggests that dyf-3 expression is regulated by DAF-19 transcription factor, and DYF-3 may be involved in the intraflagellar transport system [3].
  • The daf-19 (m86) mutation eliminates all cilia, leaving only occasional centrioles in the dendrites [4].
  • Among these are mutations in daf-8 and daf-19, genes for which only one mutation had been previously identified [5].


  1. Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Li, J.B., Gerdes, J.M., Haycraft, C.J., Fan, Y., Teslovich, T.M., May-Simera, H., Li, H., Blacque, O.E., Li, L., Leitch, C.C., Lewis, R.A., Green, J.S., Parfrey, P.S., Leroux, M.R., Davidson, W.S., Beales, P.L., Guay-Woodford, L.M., Yoder, B.K., Stormo, G.D., Katsanis, N., Dutcher, S.K. Cell (2004) [Pubmed]
  2. The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. Swoboda, P., Adler, H.T., Thomas, J.H. Mol. Cell (2000) [Pubmed]
  3. The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans. Murayama, T., Toh, Y., Ohshima, Y., Koga, M. J. Mol. Biol. (2005) [Pubmed]
  4. Mutant sensory cilia in the nematode Caenorhabditis elegans. Perkins, L.A., Hedgecock, E.M., Thomson, J.N., Culotti, J.G. Dev. Biol. (1986) [Pubmed]
  5. A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans. Malone, E.A., Thomas, J.H. Genetics (1994) [Pubmed]
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