Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

tbp-1 - Protein TBP-1

Caenorhabditis elegans

Lichtsteiner, S. et al., Dantonel, J.C. et al., Trachtulec, Z. et al., Hancock, J.M.

Trachtulec, Hamvas, Forejt, Lehrach, Vincek, Klein,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on tbp-1

Modelling of the three-dimensional structure of these TLFs suggests that they form an asymmetric saddle-like structure and that, unlike TBP, TLFs might bind to DNA sequences other than classical TATA boxes [1].
The complete amino acid sequence of CeTBP deduced from the cDNA reveals a protein of 37 kDa with an extended sequence similarity in the C-terminal region with all other TBP cDNAs sequenced so far [2].
Evolution of sequence repetition and gene duplications in the TATA-binding protein TBP (TFIID) [3].
The TATA-binding protein and proteasomal subunit C5 genes are also linked on chromosome III of Caenorhabditis elegans, and together they are linked to other genes whose homologs map to human chromosome 6 and mouse chromosome 17 [4].

Analytical, diagnostic and therapeutic context of tbp-1

We used "touch-down PCR" to generate a specific DNA probe derived from the C-terminal region conserved in all TBP genes cloned to date [2].
Protein sequence analysis has revealed a family of TATA-binding-protein (TBP)-like factors (TLFs) in metazoan organisms [1].

References

The TBP-like factor: an alternative transcription factor in metazoa? Dantonel, J.C., Wurtz, J.M., Poch, O., Moras, D., Tora, L. Trends Biochem. Sci. (1999) [Pubmed]
Cloning and properties of the Caenorhabditis elegans TATA-box-binding protein. Lichtsteiner, S., Tjian, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Evolution of sequence repetition and gene duplications in the TATA-binding protein TBP (TFIID). Hancock, J.M. Nucleic Acids Res. (1993) [Pubmed]
Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates. Trachtulec, Z., Hamvas, R.M., Forejt, J., Lehrach, H.R., Vincek, V., Klein, J. Genomics (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.