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Gene Review:

zfp-1 - Protein ZFP-1

Caenorhabditis elegans

Hla, T. et al., Cui, M. et al., Tenlen, J.R. et al., Morton, J. et al., Phillips, C.M. et al.

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High impact information on zfp-1

Zinc-finger nucleases are chimeric proteins consisting of engineered zinc-finger DNA-binding motifs attached to an endonuclease domain [1].
Reduced Dosage of pos-1 Suppresses Mex Mutants and Reveals Complex Interactions Among CCCH Zinc-Finger Proteins During Caenorhabditis elegans Embryogenesis [2].
Genetic mutations of two representative genes (zfp-1 and mes-4) were used to further characterize their positive roles in vulval induction and relationships with Ras function [3].
A Family of Zinc-Finger Proteins Is Required for Chromosome-Specific Pairing and Synapsis during Meiosis in C. elegans [4].
The deduced amino acid sequence of edg-2 contains a putative nuclear translocation sequence, an N-terminal acidic domain and a cysteine-rich C-terminal domain containing a putative Zinc-finger structure [5].

References

Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. Morton, J., Davis, M.W., Jorgensen, E.M., Carroll, D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Reduced Dosage of pos-1 Suppresses Mex Mutants and Reveals Complex Interactions Among CCCH Zinc-Finger Proteins During Caenorhabditis elegans Embryogenesis. Tenlen, J.R., Schisa, J.A., Diede, S.J., Page, B.D. Genetics (2006) [Pubmed]
Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. Cui, M., Kim, E.B., Han, M. PLoS Genet. (2006) [Pubmed]
A Family of Zinc-Finger Proteins Is Required for Chromosome-Specific Pairing and Synapsis during Meiosis in C. elegans. Phillips, C.M., Dernburg, A.F. Dev. Cell (2006) [Pubmed]
Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. Hla, T., Jackson, A.Q., Appleby, S.B., Maciag, T. Biochim. Biophys. Acta (1995) [Pubmed]

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