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Gene Review:

oxi-1 - Protein OXI-1

Caenorhabditis elegans

Lehtinen, M.K. et al., Buteau, J. et al., Essers, M.A. et al., Chen, S.R. et al.

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Disease relevance of oxi-1

The transcription factor Foxo1 protects beta-cells against oxidative stress induced by hyperglycemia and prevents beta-cell replication in insulin-resistant states [1].

High impact information on oxi-1

Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcription factors [2].
Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae [3].
Furthermore, BAR-1 was required for the oxidative stress-induced expression of the DAF-16 target gene sod-3 and for resistance to oxidative damage [4].

References

Metabolic Diapause in Pancreatic beta-Cells Expressing a Gain-of-function Mutant of the Forkhead Protein Foxo1. Buteau, J., Shlien, A., Foisy, S., Accili, D. J. Biol. Chem. (2007) [Pubmed]
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Lehtinen, M.K., Yuan, Z., Boag, P.R., Yang, Y., Villén, J., Becker, E.B., DiBacco, S., de la Iglesia, N., Gygi, S., Blackwell, T.K., Bonni, A. Cell (2006) [Pubmed]
Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae. Chen, S.R., Dunigan, D.D., Dickman, M.B. Free Radic. Biol. Med. (2003) [Pubmed]
Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Essers, M.A., de Vries-Smits, L.M., Barker, N., Polderman, P.E., Burgering, B.M., Korswagen, H.C. Science (2005) [Pubmed]

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AgaP_AGAP005897	Anopheles gambiae str. PEST
UBE3B	Bos taurus
UBE3B	Canis lupus familiaris
ube3b	Danio rerio
CG5087	Drosophila melanogaster
LOC776286	Gallus gallus
UBE3B	Homo sapiens
UBE3B	Macaca mulatta
Ube3b	Mus musculus
UBE3B	Pan troglodytes
Ube3b	Rattus norvegicus
ube3b	Xenopus (Silurana) tropicalis

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