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Gene Review

sod-3  -  Protein SOD-3

Caenorhabditis elegans

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High impact information on sod-3

  • We found that the mRNA level of the sod-3 gene, which encodes Mn-superoxide dismutase (SOD), was much higher in daf-2 mutants than in the wild type [1].
  • Moreover, the increased sod-3 gene expression phenotype is regulated by the insulin-like signaling pathway [1].
  • Two genes encoding manganese superoxide dismutase (sod-2 and sod-3) have been identified in the nematode Caenorhabditis elegans [2].
  • Expression of two superoxide dismutase genes (sod-1 and sod-3) was relatively unaffected [3].
  • Furthermore, BAR-1 was required for the oxidative stress-induced expression of the DAF-16 target gene sod-3 and for resistance to oxidative damage [4].


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