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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sod-3  -  Protein SOD-3

Caenorhabditis elegans

 
 
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High impact information on sod-3

  • We found that the mRNA level of the sod-3 gene, which encodes Mn-superoxide dismutase (SOD), was much higher in daf-2 mutants than in the wild type [1].
  • Moreover, the increased sod-3 gene expression phenotype is regulated by the insulin-like signaling pathway [1].
  • Two genes encoding manganese superoxide dismutase (sod-2 and sod-3) have been identified in the nematode Caenorhabditis elegans [2].
  • Expression of two superoxide dismutase genes (sod-1 and sod-3) was relatively unaffected [3].
  • Furthermore, BAR-1 was required for the oxidative stress-induced expression of the DAF-16 target gene sod-3 and for resistance to oxidative damage [4].

References

  1. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. Honda, Y., Honda, S. FASEB J. (1999) [Pubmed]
  2. Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans. Hunter, T., Bannister, W.H., Hunter, G.J. J. Biol. Chem. (1997) [Pubmed]
  3. Oxidative stress pretreatment increases the X-radiation resistance of the nematode Caenorhabditis elegans. Yanase, S., Hartman, P.S., Ito, A., Ishii, N. Mutat. Res. (1999) [Pubmed]
  4. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Essers, M.A., de Vries-Smits, L.M., Barker, N., Polderman, P.E., Burgering, B.M., Korswagen, H.C. Science (2005) [Pubmed]
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