Disease relevance of Msc

• Musculin/MyoR-positive cells were decreased in acute renal failure, but infusion of kidney SP cells increased musculin/MyoR-positive cells and improved renal function [1].

High impact information on Msc

• I-mf, a novel myogenic repressor, interacts with members of the MyoD family [2].
• Musculin/MyoR is a new member of basic helix-loop-helix transcription factors, and its expression is limited to skeletal muscle precursors [1].
• In cultured kidney SP cells, LIF stimulated gene expression of renoprotective factors, and down-regulation of musculin/MyoR augmented LIF-induced gene expression [1].
• We describe a bHLH protein, MyoR (for myogenic repressor), that is expressed in undifferentiated myoblasts in culture and is down-regulated during differentiation [3].
• MeAcm had little or no effect on immunoreactivity and was maximally effective in modulating dextran attachment, while NHS-Msc was much less effective [4].

Biological context of Msc

• Our data narrow the likely repressor domain to between position 158 and 173 in the Musculin protein sequence, and suggest that the induction of Musculin is responsible for the rapid down-regulation of MyoD at 4-5 days during staged regeneration [5].

Anatomical context of Msc

• In situ hybridisation revealed musculin expression in embryos was largely restricted to the embryonic skeletal muscle lineage [6].

Associations of Msc with chemical compounds

• All were reacted with citraconic anhydride followed by removal of the Msc group in III to give Ia, IIa, and IIIa, respectively [7].

Regulatory relationships of Msc

• We show that the Musculin 1b isoform is equally effective at blocking MyoD-induced transcription as the 1a isoform [5].

Other interactions of Msc

• Myogenic repressor I-mfa interferes with the function of Zic family proteins [8].

Analytical, diagnostic and therapeutic context of Msc

• Microarray analysis clarified that musculin/MyoR was exclusively expressed in kidney SP cells, and the cells resided in the renal interstitial space [1].

References