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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ama-1  -  Protein AMA-1

Caenorhabditis elegans

 
 
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High impact information on ama-1

  • By contrast with ama-1, rpc-1 was not deleted by mDf4 or larger deficiencies examined, indicating that these genes are no closer than 150 kb [1].
  • Northern (RNA) blotting and DNA sequencing revealed that ama-1 spans 10 kb, is punctuated by 11 introns, and encodes a 5.9-kb mRNA [1].
  • RNA polymerase II isolated from ama-1/+ heterozygotes contains equal proportions of two components, corresponding in alpha-amanitin sensitivity to the enzymes from DR432 and wild type [2].
  • To determine whether any early transcripts are required for normal cleavage-stage patterning, we blocked transcription in embryos by injecting hermaphrodite parental gonads with RNA antisense to the ama-1 gene, which encodes the large subunit of RNA polymerase II [3].
  • However, steady-state levels of ama-1 mRNA are directly proportional to gene dosage [4].
 

Biological context of ama-1

 

Other interactions of ama-1

  • The amanitin-binding subunit of RNA polymerase II in Caenorhabditis elegans is encoded by the ama-1 gene, located approximately 0.05 map unit to the right of dpy-13 IV [6].

References

  1. Molecular cloning and sequencing of ama-1, the gene encoding the largest subunit of Caenorhabditis elegans RNA polymerase II. Bird, D.M., Riddle, D.L. Mol. Cell. Biol. (1989) [Pubmed]
  2. RNA polymerase II from wild type and alpha-amanitin-resistant strains of Caenorhabditis elegans. Sanford, T., Golomb, M., Riddle, D.L. J. Biol. Chem. (1983) [Pubmed]
  3. Onset of C. elegans gastrulation is blocked by inhibition of embryonic transcription with an RNA polymerase antisense RNA. Powell-Coffman, J.A., Knight, J., Wood, W.B. Dev. Biol. (1996) [Pubmed]
  4. Post-transcriptional regulation of RNA polymerase II levels in Caenorhabditis elegans. Dalley, B.K., Rogalski, T.M., Tullis, G.E., Riddle, D.L., Golomb, M. Genetics (1993) [Pubmed]
  5. Lethal and amanitin-resistance mutations in the Caenorhabditis elegans ama-1 and ama-2 genes. Rogalski, T.M., Bullerjahn, A.M., Riddle, D.L. Genetics (1988) [Pubmed]
  6. A Caenorhabditis elegans RNA polymerase II gene, ama-1 IV, and nearby essential genes. Rogalski, T.M., Riddle, D.L. Genetics (1988) [Pubmed]
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