Disease relevance of phosphatase

• Only one isoform of approximately 35 kDa has been isolated from animals, where it is associated with bone resorption and microbial killing through its phosphatase activity, and hydroxyl radical production, respectively [1].

High impact information on phosphatase

• A calcineurin phosphatase antagonizes the KIN-29/MEF-2-regulated pathway to modulate levels of CR gene expression [2].
• Inactivation of the phosphatase that antagonizes AIR-2 causes premature separation of chromatids during meiosis I, in a separase-dependent reaction [3].
• Surprisingly, maturation signals then induce CTD phosphorylation that is associated specifically with transcription initiation steps and accumulates to high levels when expression of the CTD phosphatase FCP-1 is inhibited [4].
• Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine [5].
• The CDC25 dual-specificity phosphatase family has been shown to play a key role in cell cycle regulation [6].

Biological context of phosphatase

• This demonstrates that the amino terminus is not an extended catalytic domain or a direct negative regulator of phosphatase activity [7].

Anatomical context of phosphatase

• Although morphological integrity was completely restored after anthelmintic treatment, the persistent low activity of brush border alkaline phosphatase coupled with the enzymological findings in untreated, infected animals suggests that recovery of the full functional capability of the intestinal mucosa may take longer [8].

Associations of phosphatase with chemical compounds

• Cholinesterase (ChE) and acid phosphatase (AP) activities, but not alkaline phosphatase activities, were detected in cytosolic and membrane-bound fractions of adult and infective-stage larvae of levamisole-resistant and levamisole-susceptible Haemonchus contortus [9].
• Calcineurin is a calcium/calmodulin-dependent serine/ threonine protein phosphatase [10].

Other interactions of phosphatase

• At concentrations of 100 and 50 muM, the inhibition of excretion/secretion of acetylcholinesterase and acid phosphatase of adult H. polygyrus by NTZ was variable [11].

Analytical, diagnostic and therapeutic context of phosphatase

• Acid phosphatase typing for breeding nematode-resistant tomatoes by isoelectric focusing with an ultranarrow immobilized pH gradient [12].

References