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Gene Review

T12B3.1  -  Protein T12B3.1

Caenorhabditis elegans

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Disease relevance of phosphatase

  • Only one isoform of approximately 35 kDa has been isolated from animals, where it is associated with bone resorption and microbial killing through its phosphatase activity, and hydroxyl radical production, respectively [1].

High impact information on phosphatase

  • A calcineurin phosphatase antagonizes the KIN-29/MEF-2-regulated pathway to modulate levels of CR gene expression [2].
  • Inactivation of the phosphatase that antagonizes AIR-2 causes premature separation of chromatids during meiosis I, in a separase-dependent reaction [3].
  • Surprisingly, maturation signals then induce CTD phosphorylation that is associated specifically with transcription initiation steps and accumulates to high levels when expression of the CTD phosphatase FCP-1 is inhibited [4].
  • Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine [5].
  • The CDC25 dual-specificity phosphatase family has been shown to play a key role in cell cycle regulation [6].

Biological context of phosphatase


Anatomical context of phosphatase

  • Although morphological integrity was completely restored after anthelmintic treatment, the persistent low activity of brush border alkaline phosphatase coupled with the enzymological findings in untreated, infected animals suggests that recovery of the full functional capability of the intestinal mucosa may take longer [8].

Associations of phosphatase with chemical compounds


Other interactions of phosphatase


Analytical, diagnostic and therapeutic context of phosphatase


  1. Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Flanagan, J.U., Cassady, A.I., Schenk, G., Guddat, L.W., Hume, D.A. Gene (2006) [Pubmed]
  2. KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. van der Linden, A.M., Nolan, K.M., Sengupta, P. EMBO J. (2007) [Pubmed]
  3. The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. Kaitna, S., Pasierbek, P., Jantsch, M., Loidl, J., Glotzer, M. Curr. Biol. (2002) [Pubmed]
  4. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Walker, A.K., Boag, P.R., Blackwell, T.K. Dev. Biol. (2007) [Pubmed]
  5. Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine. Fukushige, T., Goszczynski, B., Yan, J., McGhee, J.D. Dev. Biol. (2005) [Pubmed]
  6. RNA-Mediated interference of a cdc25 homolog in Caenorhabditis elegans results in defects in the embryonic cortical membrane, meiosis, and mitosis. Ashcroft, N.R., Srayko, M., Kosinski, M.E., Mains, P.E., Golden, A. Dev. Biol. (1999) [Pubmed]
  7. Molecular evolution of a sex determination protein. FEM-2 (pp2c) in Caenorhabditis. Hansen, D., Pilgrim, D. Genetics (1998) [Pubmed]
  8. Intestinal enzyme activity in lambs chronically infected with Trichostrongylus colubriformis: effect of anthelmintic treatment. Jones, D.G. Vet. Parasitol. (1983) [Pubmed]
  9. Cholinesterase and phosphatase activities in adults and infective-stage larvae of levamisole-resistant and levamisole-susceptible isolates of Haemonchus contortus. Giménez-Pardo, C., Martínez-Grueiro, M.M., Gómez-Barrio, A., Rodríguez-Caabeiro, F. Vet. Res. Commun. (2003) [Pubmed]
  10. Regulation of calcineurin, a calcium/calmodulin-dependent protein phosphatase, in C. elegans. Bandyopadhyay, J., Lee, J., Bandyopadhyay, A. Mol. Cells (2004) [Pubmed]
  11. Nematocidal activity of nitazoxanide in laboratory models. Fonseca-Salamanca, F., Martínez-Grueiro, M.M., Martínez-Fernández, A.R. Parasitol. Res. (2003) [Pubmed]
  12. Acid phosphatase typing for breeding nematode-resistant tomatoes by isoelectric focusing with an ultranarrow immobilized pH gradient. Günther, S., Postel, W., Wiering, H., Görg, A. Electrophoresis (1988) [Pubmed]
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