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Gene Review

cpt-4  -  Protein CPT-4

Caenorhabditis elegans

 
 
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High impact information on acetyltransferase

  • In Caenorhabditis elegans, histone acetyltransferase CBP-1 counteracts the repressive activity of the histone deacetylase HDA-1 to allow endoderm differentiation, which is specified by the E cell [1].
  • A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras [2].
  • As other Spr genes encode proteins homologous to components of the CoREST co-repressor complex that interacts with REST, and the INHAT (inhibitor of acetyltransferase) co-repressor complex, our data suggest that all Spr genes may function through the same mechanism that involves transcriptional repression of the hop-1 locus [3].
  • These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegans Tip60/NuA4-like histone acetyltransferase complex [4].
  • In addition to identifying putative nematode-specific and Tylenchida-specific genes, sequencing revealed previously uncharacterized horizontal gene transfer candidates in Meloidogyne with high identity to rhizobacterial genes including homologs of nodL acetyltransferase and novel cellulases [5].

References

  1. A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis. Calvo, D., Victor, M., Gay, F., Sui, G., Luke, M.P., Dufourcq, P., Wen, G., Maduro, M., Rothman, J., Shi, Y. EMBO J. (2001) [Pubmed]
  2. A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras. Eastburn, D.J., Han, M. Mol. Cell. Biol. (2005) [Pubmed]
  3. Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans. Lakowski, B., Eimer, S., Göbel, C., Böttcher, A., Wagler, B., Baumeister, R. Development (2003) [Pubmed]
  4. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Ceol, C.J., Horvitz, H.R. Dev. Cell (2004) [Pubmed]
  5. Analysis and functional classification of transcripts from the nematode Meloidogyne incognita. McCarter, J.P., Mitreva, M.D., Martin, J., Dante, M., Wylie, T., Rao, U., Pape, D., Bowers, Y., Theising, B., Murphy, C.V., Kloek, A.P., Chiapelli, B.J., Clifton, S.W., Bird, D.M., Waterston, R.H. Genome Biol. (2003) [Pubmed]
 
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