The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tylenchoidea

  • In Pseudomonas fluorescens CHA0, mutation of the GacA-controlled aprA gene (encoding the major extracellular protease) or the gacA regulatory gene resulted in reduced biocontrol activity against the root-knot nematode Meloidogyne incognita during tomato and soybean infection [1].
  • Recombinant propeptides of HGCP-Iv, expressed in E. coli, presented high inhibitory activity in vitro towards its cognate enzyme and proteinase activity of Meloidogyne incognita females, suggesting its usefulness in inhibiting nematode CPs in biological systems [2].

High impact information on Tylenchoidea

  • One mutant was chosen for further analyzes; rme1 (for resistance to Meloidogyne) exhibited levels of infection comparable with those found on susceptible controls [3].
  • This species-related efficiency of plant cystatins against nematode cysteine proteinases could have practical implications when planning their use to control nematodes of the genus Meloidogyne [4].
  • Proteins of young single Meloidogyne females were separated using polyacrylamide gradient gels and stained for the isozymes esterase and malate dehydrogenase [5].
  • Eggplants that carried Mi-1.2 displayed resistance to the root-knot nematode Meloidogyne javanica but were fully susceptible to the potato aphid, whereas a susceptible tomato line transformed with the same transgene was resistant to nematodes and aphids [6].
  • Analysis of chitin synthase function in a plant parasitic nematode, Meloidogyne artiellia, using RNAi [7].

Chemical compound and disease context of Tylenchoidea


Biological context of Tylenchoidea

  • Here, we describe the application of RNA interference (RNAi) to the root-knot nematode Meloidogyne incognita for the knock-down of two genes expressed in the subventral esophageal glands of the nematode and potentially involved in parasitism, the calreticulin (Mi-crt) and the polygalacturonase (Mi-pg-1) genes [9].
  • Two cDNAs (designated Mi-pel-1 and Mi-pel-2) encoding pectate lyases were isolated from the root-knot nematode, Meloidogyne incognita, oesophageal gland-cell subtractive cDNA libraries, and the corresponding genomic DNAs were subsequently cloned [10].
  • Southern blot analyses revealed that homologues to these pectate lyase genes were broadly distributed in Meloidogyne species, and present as members of a small multigene family [10].
  • In addition to identifying putative nematode-specific and Tylenchida-specific genes, sequencing revealed previously uncharacterized horizontal gene transfer candidates in Meloidogyne with high identity to rhizobacterial genes including homologs of nodL acetyltransferase and novel cellulases [11].

Associations of Tylenchoidea with chemical compounds

  • Cloning and characterization of an esophageal-gland-specific pectate lyase from the root-knot nematode Meloidogyne javanica [12].
  • Meloidogyne javanica chorismate mutase 1 alters plant cell development [13].
  • A basic serine protease from Paecilomyces lilacinus with biological activity against Meloidogyne hapla eggs [14].
  • Colloidal chitin, vitellin and intact eggs of the root-knot nematode Meloidogyne hapla induced proteolytic activity that was repressed by glucose [14].
  • Saturation of the phytosterol nucleus was the major metabolic transformation performed by the root-knot nematodes Meloidogyne arenaria and M. incognita and the corn root lesion nematode, Pratylenchus agilis [15].

Gene context of Tylenchoidea


Analytical, diagnostic and therapeutic context of Tylenchoidea

  • Molecular cloning and characterisation of a venom allergen AG5-like cDNA from Meloidogyne incognita [21].
  • Western blot analysis with monoclonal and polyclonal antibodies that recognize the 30 kDa heparin-binding domain (HBD) and the 45 kDa gelatin-binding domain (GBD) fragments of human fibronectin (Fn) revealed a series of polypeptides of approximately 40, 45 and 55 kDa present in crude cuticle extracts of Meloidogyne javanica 2nd-stage juveniles [22].


  1. Extracellular protease of Pseudomonas fluorescens CHA0, a biocontrol factor with activity against the root-knot nematode Meloidogyne incognita. Siddiqui, I.A., Haas, D., Heeb, S. Appl. Environ. Microbiol. (2005) [Pubmed]
  2. Pro domain peptide of HGCP-Iv cysteine proteinase inhibits nematode cysteine proteinases. Silva, F.B., Batista, J.A., Marra, B.M., Fragoso, R.R., Monteiro, A.C., Figueira, E.L., Grossi-de-Sá, M.F. Genet. Mol. Res. (2004) [Pubmed]
  3. The tomato Rme1 locus is required for Mi-1-mediated resistance to root-knot nematodes and the potato aphid. de Ilarduya, O.M., Moore, A.E., Kaloshian, I. Plant J. (2001) [Pubmed]
  4. Identification of stable plant cystatin/nematode proteinase complexes using mildly denaturing gelatin/polyacrylamide gel electrophoresis. Michaud, D., Cantin, L., Bonadé-Bottino, M., Jouanin, L., Vrain, T.C. Electrophoresis (1996) [Pubmed]
  5. Species identification of cyst and root-knot nematodes from potato by electrophoresis of individual females. Karssen, G., van Hoenselaar, T., Verkerk-Bakker, B., Janssen, R. Electrophoresis (1995) [Pubmed]
  6. Heterologous expression of the Mi-1.2 gene from tomato confers resistance against nematodes but not aphids in eggplant. Goggin, F.L., Jia, L., Shah, G., Hebert, S., Williamson, V.M., Ullman, D.E. Mol. Plant Microbe Interact. (2006) [Pubmed]
  7. Analysis of chitin synthase function in a plant parasitic nematode, Meloidogyne artiellia, using RNAi. Fanelli, E., Di Vito, M., Jones, J.T., De Giorgi, C. Gene (2005) [Pubmed]
  8. Improvement of Pseudomonas fluorescens CHA0 biocontrol activity against root-knot nematode by the addition of ammonium molybdate. Hamid, M., Siddiqui, I.A., Shahid Shaukat, S. Lett. Appl. Microbiol. (2003) [Pubmed]
  9. Application of RNA interference to root-knot nematode genes encoding esophageal gland proteins. Rosso, M.N., Dubrana, M.P., Cimbolini, N., Jaubert, S., Abad, P. Mol. Plant Microbe Interact. (2005) [Pubmed]
  10. Developmental expression and molecular analysis of two Meloidogyne incognita pectate lyase genes. Huang, G., Dong, R., Allen, R., Davis, E.L., Baum, T.J., Hussey, R.S. Int. J. Parasitol. (2005) [Pubmed]
  11. Analysis and functional classification of transcripts from the nematode Meloidogyne incognita. McCarter, J.P., Mitreva, M.D., Martin, J., Dante, M., Wylie, T., Rao, U., Pape, D., Bowers, Y., Theising, B., Murphy, C.V., Kloek, A.P., Chiapelli, B.J., Clifton, S.W., Bird, D.M., Waterston, R.H. Genome Biol. (2003) [Pubmed]
  12. Cloning and characterization of an esophageal-gland-specific pectate lyase from the root-knot nematode Meloidogyne javanica. Doyle, E.A., Lambert, K.N. Mol. Plant Microbe Interact. (2002) [Pubmed]
  13. Meloidogyne javanica chorismate mutase 1 alters plant cell development. Doyle, E.A., Lambert, K.N. Mol. Plant Microbe Interact. (2003) [Pubmed]
  14. A basic serine protease from Paecilomyces lilacinus with biological activity against Meloidogyne hapla eggs. Bonants, P.J., Fitters, P.F., Thijs, H., den Belder, E., Waalwijk, C., Henfling, J.W. Microbiology (Reading, Engl.) (1995) [Pubmed]
  15. Metabolism of plant sterols by nematodes. Chitwood, D.J., Lusby, W.R. Lipids (1991) [Pubmed]
  16. Characterization of acetylcholinesterase molecular forms of the root-knot nematode, Meloidogyne. Chang, S., Opperman, C.H. Mol. Biochem. Parasitol. (1991) [Pubmed]
  17. cDNA cloning and expression analysis of a calponin gene from the plant-parasitic nematode Meloidogyne incognita. Castagnone-Sereno, P., Leroy, F., Abad, P. Mol. Biochem. Parasitol. (2001) [Pubmed]
  18. A silent trans-splicing signal in the cuticlin-encoding gene of the plant-parasitic nematode Meloidogyne artiellia. De Giorgi, C., De Luca, F., Lamberti, F. Gene (1996) [Pubmed]
  19. In planta secretion of a calreticulin by migratory and sedentary stages of root-knot nematode. Jaubert, S., Milac, A.L., Petrescu, A.J., de Almeida-Engler, J., Abad, P., Rosso, M.N. Mol. Plant Microbe Interact. (2005) [Pubmed]
  20. RNA interference of dual oxidase in the plant nematode Meloidogyne incognita. Bakhetia, M., Charlton, W., Atkinson, H.J., McPherson, M.J. Mol. Plant Microbe Interact. (2005) [Pubmed]
  21. Molecular cloning and characterisation of a venom allergen AG5-like cDNA from Meloidogyne incognita. Ding, X., Shields, J., Allen, R., Hussey, R.S. Int. J. Parasitol. (2000) [Pubmed]
  22. The interaction between the gelatin-binding domain of fibronectin and the attachment of Pasteuria penetrans endospores to nematode cuticle. Mohan, S., Fould, S., Davies, K.G. Parasitology (2001) [Pubmed]
WikiGenes - Universities