The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

cat-4  -  Protein CAT-4

Caenorhabditis elegans

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on cat-4

  • Males mutant in three different genes that reduce serotonin expression, cat-1, cat-4, and bas-1, exhibited defects in turning behavior similar to those of wild-type males in which these neurons were ablated [1].
  • The turning defect of cat-4 males was rescued by exogenous serotonin, consistent with the idea that their behavioral defect is caused by a lack of serotonin [1].
  • Imipramine stimulation is greatly decreased in cat-1 and cat-4 mutants, which have low levels of serotonin [2].
  • Concentration-response curves for the toxicants arsenite and aldicarb, both of which affect motility, were determined for wild-type and several mutant strains, identifying P-glycoprotein mutants as not significantly more sensitive to either compound, while cat-4 mutants are more sensitive to arsenite but not aldicarb [3].

References

  1. Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans. Loer, C.M., Kenyon, C.J. J. Neurosci. (1993) [Pubmed]
  2. Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. Avery, L., Horvitz, H.R. J. Exp. Zool. (1990) [Pubmed]
  3. An automated system for measuring parameters of nematode sinusoidal movement. Cronin, C.J., Mendel, J.E., Mukhtar, S., Kim, Y.M., Stirbl, R.C., Bruck, J., Sternberg, P.W. BMC Genet. (2005) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities