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Chemical Compound Review

AG-K-77369     [(2-methyl-2-methylsulfanyl...

Synonyms: KBioGR_001183, KBioSS_002455, DSSTox_CID_39, AC1L1CVX, ACT08736, ...
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Disease relevance of aldicarb


Psychiatry related information on aldicarb

  • Motor activity assessment showed that aldicarb did not produce any activity depression in PND17 rats, whereas the data for the PND27 and adult rats overlapped [6].
  • The neuropharmacologic effects of chronic dosing with aldicarb, AChE inhibition and dopaminergic modulation could be useful for treatment of memory deficits related to CNS disorders [7].

High impact information on aldicarb


Chemical compound and disease context of aldicarb


Biological context of aldicarb


Anatomical context of aldicarb


Associations of aldicarb with other chemical compounds


Gene context of aldicarb


Analytical, diagnostic and therapeutic context of aldicarb

  • Determination of aldicarb and its derivatives in groundwater by high-performance liquid chromatography with UV detection [32].
  • Aldicarb administered at concentrations less than 0.005 microgram/kg body wt failed to cause significant immunosuppression [23].
  • Construction of an acetylcholinesterase-choline oxidase biosensor for aldicarb determination [33].
  • No correlation existed between CYP isoform expression (determined by western blot) and aldicarb sulfoxidation rates, suggesting the involvement of an unmeasured CYP isoform or involvement of several isoforms with low specificity [34].
  • Adding a fourth sensor (neuronal microelectrode array) to the test battery allowed detection of two additional chemicals (aldicarb and methamidophos), but the neuronal microelectrode array was overly sensitive to paraquat [35].


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  2. Effect of 17beta-estradiol and testosterone on the expression of flavin-containing monooxygenase and the toxicity of aldicarb to Japanese medaka, Oryzias latipes. El-Alfy, A.T., Schlenk, D. Toxicol. Sci. (2002) [Pubmed]
  3. Chromosomal aberrations in cultured human lymphocytes treated with aldicarb, a carbamate pesticide. González Cid, M., Matos, E. Mutat. Res. (1987) [Pubmed]
  4. Toxicity of aldicarb in young chicks. Farage-Elawar, M. Neurotoxicology and teratology. (1988) [Pubmed]
  5. Effect of culture acclimation on the kinetics of aldicarb insecticide degradation under methanogenic conditions. Khandaker, N.R., Young, J.C. J. Agric. Food Chem. (2000) [Pubmed]
  6. Comparison of aldicarb and methamidophos neurotoxicity at different ages in the rat: behavioral and biochemical parameters. Moser, V.C. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  7. Neurochemical and behavioural effects of chronic aldicarb administration in rats. Palumbo, G., Bacchi, S., Coppolino, M.F., Pantaleoni, G.C. Pharmacol. Toxicol. (2001) [Pubmed]
  8. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Miller, K.G., Emerson, M.D., McManus, J.R., Rand, J.B. Neuron (2000) [Pubmed]
  9. Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites. Nurrish, S., Ségalat, L., Kaplan, J.M. Neuron (1999) [Pubmed]
  10. Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. Nonet, M.L., Staunton, J.E., Kilgard, M.P., Fergestad, T., Hartwieg, E., Horvitz, H.R., Jorgensen, E.M., Meyer, B.J. J. Neurosci. (1997) [Pubmed]
  11. A Na+/Cl- -coupled GABA transporter, GAT-1, from Caenorhabditis elegans: structural and functional features, specific expression in GABA-ergic neurons, and involvement in muscle function. Jiang, G., Zhuang, L., Miyauchi, S., Miyake, K., Fei, Y.J., Ganapathy, V. J. Biol. Chem. (2005) [Pubmed]
  12. The toxicologic effects of the carbamate insecticide aldicarb in mammals: a review. Risher, J.F., Mink, F.L., Stara, J.F. Environ. Health Perspect. (1987) [Pubmed]
  13. Assessment of the ability of propoxur, methomyl, and aldicarb, three carbamate insecticides, to induce micronuclei in vitro in cultured Chinese hamster ovary cells and in vivo in BALB/c mice. Wei, L.Y., Chao, J.S., Hong, C.C. Environ. Mol. Mutagen. (1997) [Pubmed]
  14. The toxicity of Temik (aldicarb) in Nubian goats. Mohamed, O.S., Adam, S.E. Br. Vet. J. (1990) [Pubmed]
  15. Individual and combined toxicity of common pesticides to teleost Puntius conchonius Hamilton. Gill, T.S., Pande, J., Tewari, H. Indian J. Exp. Biol. (1991) [Pubmed]
  16. Breast cancer incidence and its possible spatial association with pesticide application in two counties of England. Muir, K., Rattanamongkolgul, S., Smallman-Raynor, M., Thomas, M., Downer, S., Jenkinson, C. Public health. (2004) [Pubmed]
  17. The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion. Pilon, M., Peng, X.R., Spence, A.M., Plasterk, R.H., Dosch, H.M. Mol. Biol. Cell (2000) [Pubmed]
  18. In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity. Perkins, E.J., Schlenk, D. Toxicol. Sci. (2000) [Pubmed]
  19. Induction of sister-chromatid exchanges in cultured human lymphocytes by Aldicarb, a carbamate pesticide. Cid, M.G., Matos, E. Mutat. Res. (1984) [Pubmed]
  20. Potential mechanisms of the enhancement of aldicarb toxicity to Japanese medaka, Oryzias latipes, at high salinity. El-Alfy, A., Schlenk, D. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  21. Isocratic high-performance liquid chromatographic separation and multiple-wavelength ultraviolet detection of aldicarb and its soil degradation products. Optimization of stationary phase selectivity. Lin, L.Y., Cooper, W.T. J. Chromatogr. (1987) [Pubmed]
  22. Carbamate poisoning and oxime treatment in children: a clinical and laboratory study. Lifshitz, M., Rotenberg, M., Sofer, S., Tamiri, T., Shahak, E., Almog, S. Pediatrics (1994) [Pubmed]
  23. Immunosuppression by aldicarb of T cell responses to antigen-specific and polyclonal stimuli results from defective IL-1 production by the macrophages. Dean, T.N., Kakkanaiah, V.N., Nagarkatti, M., Nagarkatti, P.S. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  24. Effects of salinity on aldicarb toxicity in juvenile rainbow trout (Oncorhynchus mykiss) and striped bass (Morone saxatilis x chrysops). Wang, J., Grisle, S., Schlenk, D. Toxicol. Sci. (2001) [Pubmed]
  25. Gas chromatographic determination of aldicarb and its metabolites in urine. Lian, D.X., Yang, L., Yun, W.X., Hua, S., Hu, C. J. Chromatogr. (1991) [Pubmed]
  26. Rapid on-line precolumn high-performance liquid chromatographic method for the determination of benomyl, carbendazim and aldicarb species in drinking water. Marvin, C.H., Brindle, I.D., Hall, C.D., Chiba, M. J. Chromatogr. (1991) [Pubmed]
  27. Modification of mipafox-induced inhibition of neuropathy target esterase in neuroblastoma cells of human origin. Nostrandt, A.C., Ehrich, M. Toxicol. Appl. Pharmacol. (1993) [Pubmed]
  28. Neuronal uptake of pesticides disrupts chemosensory cells of nematodes. Winter, M.D., McPherson, M.J., Atkinson, H.J. Parasitology (2002) [Pubmed]
  29. Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission. Bessou, C., Giugia, J.B., Franks, C.J., Holden-Dye, L., Ségalat, L. Neurogenetics (1998) [Pubmed]
  30. Differential toxicities of organophosphate and carbamate insecticides in the nestling European starling (Sturnus vulgaris). Parker, M.L., Goldstein, M.I. Arch. Environ. Contam. Toxicol. (2000) [Pubmed]
  31. An automated system for measuring parameters of nematode sinusoidal movement. Cronin, C.J., Mendel, J.E., Mukhtar, S., Kim, Y.M., Stirbl, R.C., Bruck, J., Sternberg, P.W. BMC Genet. (2005) [Pubmed]
  32. Determination of aldicarb and its derivatives in groundwater by high-performance liquid chromatography with UV detection. Miles, C.J., Delfino, J.J. J. Chromatogr. (1984) [Pubmed]
  33. Construction of an acetylcholinesterase-choline oxidase biosensor for aldicarb determination. Kok, F.N., Bozoglu, F., Hasirci, V. Biosensors & bioelectronics. (2002) [Pubmed]
  34. In vitro sulfoxidation of aldicarb by hepatic microsomes of channel catfish, Ictalurus punctatus. Perkins, E.J., el-Alfy, A., Schlenk, D. Toxicol. Sci. (1999) [Pubmed]
  35. Selection of a battery of rapid toxicity sensors for drinking water evaluation. van der Schalie, W.H., James, R.R., Gargan, T.P. Biosensors & bioelectronics. (2006) [Pubmed]
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