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Gene Review:

FOL2 - GTP cyclohydrolase I

Saccharomyces cerevisiae S288c

Synonyms: G9349, GTP cyclohydrolase 1, GTP-CH-I, YGR267C

Mancini, R. et al., Agostoni Carbone, M.L. et al.

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Disease relevance of FOL2

Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I [1].

High impact information on FOL2

Since deletion of yeast FOL2 leads to a recessive auxotrophy for folinic acid, we used a yeast fol2Delta mutant for an in vivo functional assay of heterologous GTP cyclohydrolases I [1].
A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames [2].

References

Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I. Mancini, R., Saracino, F., Buscemi, G., Fischer, M., Schramek, N., Bracher, A., Bacher, A., Gütlich, M., Carbone, M.L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
A 9359 bp fragment from the right arm of Saccharomyces cerevisiae chromosome VII includes the FOL2 and YTA7 genes and three unknown open reading frames. Agostoni Carbone, M.L., Lucchini, G., Melchioretto, P., Nardese, V., Vanoni, M., Panzeri, L. Yeast (1998) [Pubmed]

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