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Gene Review: 

Nfs1  -  nitrogen fixation gene 1 (S. cerevisiae)

Mus musculus

Synonyms: AA987187, Cysteine desulfurase, mitochondrial, Nifs, m-Nfs1, m-Nfsl
 
 
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High impact information on Nfs1

  • Nuclear localization of yeast Nfs1p is required for cell survival [1].
  • However, this mutation did not affect the function of Nfs1p in biogenesis of mitochondrial iron-sulfur proteins [1].
  • The deduced protein sequence (459 amino acids long) has several characteristic features common to those of bacterial NifS proteins, but distinct from them by its amino-terminal extension which contains a typical mitochondrial targeting presequence. m-Nfs1 was found to be a soluble 47-kDa protein in the matrix fraction of mouse liver mitochondria [2].

References

  1. Nuclear localization of yeast Nfs1p is required for cell survival. Nakai, Y., Nakai, M., Hayashi, H., Kagamiyama, H. J. Biol. Chem. (2001) [Pubmed]
  2. cDNA cloning and characterization of mouse nifS-like protein, m-Nfs1: mitochondrial localization of eukaryotic NifS-like proteins. Nakai, Y., Yoshihara, Y., Hayashi, H., Kagamiyama, H. FEBS Lett. (1998) [Pubmed]
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