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Gene Review

NFS1  -  NFS1 cysteine desulfurase

Homo sapiens

Synonyms: Cysteine desulfurase, mitochondrial, HUSSY-08, IscS, NIFS, NifS
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High impact information on NFS1

  • It forms a complex with the cysteine desulfurase Nfs1 and is required for formation of an Fe/S cluster on the Isu scaffold proteins [1].
  • Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation [2].
  • The NIFS protein can function as a selenide delivery protein in the biosynthesis of selenophosphate [3].
  • These results thus support the view that a selenocysteine-specific enzyme similar to NIFS may be involved as an in vivo selenide delivery protein for selenophosphate biosynthesis [3].
  • The nifS gene product (NIFS) is a pyridoxal phosphate binding enzyme that catalyzes the desulfurization of L-cysteine to yield L-alanine and sulfur [4].

Biological context of NFS1

  • First, the substrate analogs, L-allylglycine and vinylglycine, were shown to irreversibly inactivate NIFS by formation of a gamma-methylcystathionyl or cystathionyl residue, respectively, through nucleophilic attack by an active site cysteinyl residue on the corresponding analog-pyridoxal phosphate adduct [4].

Anatomical context of NFS1

  • The anti-Plasmodium falciparum antibodies evaluated with the test included monoclonal antibodies (MAbs) NFS1 and NFS2 as well as polyclonal antibodies contained in human hyperimmune sera directed against sporozoites of P. falciparum [5].

Associations of NFS1 with chemical compounds

  • The fact that NIFS also can catalyze the decomposition of L-selenocysteine to elemental selenium and L-alanine suggested the possibility that this enzyme might serve as a selenide delivery protein for the in vitro biosynthesis of selenophosphate [3].
  • In this report, we investigated the involvement of the human L-cysteine desulfurase Nfs1 in sulfur transfer to MOCS3-RLD [6].


  1. Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. Wiedemann, N., Urzica, E., Guiard, B., Müller, H., Lohaus, C., Meyer, H.E., Ryan, M.T., Meisinger, C., Mühlenhoff, U., Lill, R., Pfanner, N. EMBO J. (2006) [Pubmed]
  2. Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. Biederbick, A., Stehling, O., Rösser, R., Niggemeyer, B., Nakai, Y., Elsässer, H.P., Lill, R. Mol. Cell. Biol. (2006) [Pubmed]
  3. The NIFS protein can function as a selenide delivery protein in the biosynthesis of selenophosphate. Lacourciere, G.M., Stadtman, T.C. J. Biol. Chem. (1998) [Pubmed]
  4. Mechanism for the desulfurization of L-cysteine catalyzed by the nifS gene product. Zheng, L., White, R.H., Cash, V.L., Dean, D.R. Biochemistry (1994) [Pubmed]
  5. Evaluation of an in vitro assay aimed at measuring protective antibodies against sporozoites. Mellouk, S., Berbiguier, N., Druilhe, P., Sedegah, M., Galey, B., Yuan, L., Leef, M., Charoenvit, Y., Paul, C., Hoffman, S. Bull. World Health Organ. (1990) [Pubmed]
  6. A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis. Marelja, Z., Stöcklein, W., Nimtz, M., Leimkühler, S. J. Biol. Chem. (2008) [Pubmed]
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