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Gene Review:

aex-3 - Protein AEX-3

Caenorhabditis elegans

Mahoney, T.R. et al., Iwasaki, K. et al., Iwasaki, K. et al.

Iwasaki, Toyonaga,

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High impact information on aex-3

C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission [1].
The aex-3 mutant phenotype resembles the sum of the rab-3 and cab-1 mutant phenotypes, indicating that AEX-3 regulates two different pathways for neural activities [2].
Interestingly, aex-6 mutants exhibit the same defecation defect as aex-3 mutants. aex-6; rab-3 double mutants have behavioral and pharmacological defects similar to aex-3 mutants [3].

Biological context of aex-3

Unexpectedly, mutations in the Caenorhabditis elegans RAB-3 exchange factor homologue, aex-3, cause a more severe synaptic transmission defect as well as a defecation defect not seen in rab-3 mutants [3].

References

aex-3 encodes a novel regulator of presynaptic activity in C. elegans. Iwasaki, K., Staunton, J., Saifee, O., Nonet, M., Thomas, J.H. Neuron (1997) [Pubmed]
The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission. Iwasaki, K., Toyonaga, R. EMBO J. (2000) [Pubmed]
Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mahoney, T.R., Liu, Q., Itoh, T., Luo, S., Hadwiger, G., Vincent, R., Wang, Z.W., Fukuda, M., Nonet, M.L. Mol. Biol. Cell (2006) [Pubmed]

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AgaP_AGAP000630	Anopheles gambiae str. PEST
MADD	Bos taurus
MADD	Canis lupus familiaris
madd	Danio rerio
Rab3-GEF	Drosophila melanogaster
MADD	Gallus gallus
MADD	Homo sapiens
MADD	Macaca mulatta
Madd	Mus musculus
MADD	Pan troglodytes
Madd	Rattus norvegicus
madd	Xenopus (Silurana) tropicalis

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