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Gene Review:

rab-3 - Protein RAB-3

Caenorhabditis elegans

Mahoney, T.R. et al., Nonet, M.L. et al., Staunton, J. et al.

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High impact information on rab-3

Furthermore, rab-3 animals were resistant to the acetylcholinesterase inhibitor aldicarb, suggesting that cholinergic transmission was generally depressed [1].
Last, synaptic vesicle populations were redistributed in rab-3 mutants [1].
To elucidate the role of rab3 in synaptic transmission, we isolated and characterized Caenorhabditis elegans rab-3 mutants [1].
Interestingly, aex-6 mutants exhibit the same defecation defect as aex-3 mutants. aex-6; rab-3 double mutants have behavioral and pharmacological defects similar to aex-3 mutants [2].
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3 [3].

Biological context of rab-3

Unexpectedly, mutations in the Caenorhabditis elegans RAB-3 exchange factor homologue, aex-3, cause a more severe synaptic transmission defect as well as a defecation defect not seen in rab-3 mutants [2].

References

Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. Nonet, M.L., Staunton, J.E., Kilgard, M.P., Fergestad, T., Hartwieg, E., Horvitz, H.R., Jorgensen, E.M., Meyer, B.J. J. Neurosci. (1997) [Pubmed]
Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mahoney, T.R., Liu, Q., Itoh, T., Luo, S., Hadwiger, G., Vincent, R., Wang, Z.W., Fukuda, M., Nonet, M.L. Mol. Biol. Cell (2006) [Pubmed]
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3. Staunton, J., Ganetzky, B., Nonet, M.L. J. Neurosci. (2001) [Pubmed]

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AgaP_AGAP005255	Anopheles gambiae str. PEST
RAB3C	Bos taurus
RAB3C	Canis lupus familiaris
rab3c	Danio rerio
Rab3	Drosophila melanogaster
RAB3C	Gallus gallus
RAB3C	Homo sapiens
RAB3C	Macaca mulatta
Rab3c	Mus musculus
RAB3C	Pan troglodytes
Rab3c	Rattus norvegicus
rab3c	Xenopus (Silurana) tropicalis

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