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Gene Review

unc-31  -  Protein UNC-31

Caenorhabditis elegans

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High impact information on unc-31

  • C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission [1].
  • Epistasis experiments place unc-64 and unc-31 at a different position in the dauer pathway from unc-3 [2].
  • Cloning within the unc-43 to unc-31 interval (linkage group IV) of the Caenorhabditis elegans genome using Tc1 linkage selection [3].
  • The region around the twitcher gene, unc-22, flanked by unc-43 on the left and by unc-31 on the right, has been intensively studied in our laboratory over the period of the last 8 years [3].

Associations of unc-31 with chemical compounds

  • These were recovered from a lambda gt 10 library of DNA from a specially constructed genetic strain containing the unc-43 to unc-31 interval from the BO strain and the rest of the genome from N2 [3].


  1. aex-3 encodes a novel regulator of presynaptic activity in C. elegans. Iwasaki, K., Staunton, J., Saifee, O., Nonet, M., Thomas, J.H. Neuron (1997) [Pubmed]
  2. Dauer formation induced by high temperatures in Caenorhabditis elegans. Ailion, M., Thomas, J.H. Genetics (2000) [Pubmed]
  3. Cloning within the unc-43 to unc-31 interval (linkage group IV) of the Caenorhabditis elegans genome using Tc1 linkage selection. Baillie, D.L., Beckenbach, K.A., Rose, A.M. Can. J. Genet. Cytol. (1985) [Pubmed]
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