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Gene Review:

hbl-1 - Protein HBL-1

Caenorhabditis elegans

Abrahante, J.E. et al., Abbott, A.L. et al., Lin, S.Y. et al., Fay, D.S. et al.

Fay, Stanley, Han, Wood,

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High impact information on hbl-1

Double-stranded RNA-interference (RNAi) was used to indicate hbl-1 loss-of-function phenotypes [1].
Triply mutant animals lacking mir-48, mir-84, and mir-241 exhibit repetition of L2-stage events in addition to retarded adult-stage events. mir-48, mir-84, and mir-241 function together to control the L2-to-L3 transition, likely by base pairing to complementary sites in the hbl-1 3' UTR and downregulating hbl-1 activity [2].
Like lin-41 mutations, hbl-1 loss-of-function partially suppresses a let-7 mutation [3].
Loss of lin-57 function causes the hypodermis to terminally differentiate and acquire adult character prematurely. lin-57 is hbl-1, revealing a role for the worm hunchback homolog in control of developmental time [4].
The hbl-1 3'UTR is both necessary and sufficient to downregulate a reporter gene during development, and the let-7 and lin-4 microRNAs are both required for HBL-1/GFP downregulation [3].

Biological context of hbl-1

The hbl-1/lin-57 3'UTR is required for postembryonic downregulation in the hypodermis and nervous system and contains multiple putative binding sites for temporally regulated microRNAs, including let-7 [4].

References

A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterning. Fay, D.S., Stanley, H.M., Han, M., Wood, W.B. Dev. Biol. (1999) [Pubmed]
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Abbott, A.L., Alvarez-Saavedra, E., Miska, E.A., Lau, N.C., Bartel, D.P., Horvitz, H.R., Ambros, V. Dev. Cell (2005) [Pubmed]
The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Lin, S.Y., Johnson, S.M., Abraham, M., Vella, M.C., Pasquinelli, A., Gamberi, C., Gottlieb, E., Slack, F.J. Dev. Cell (2003) [Pubmed]
The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Abrahante, J.E., Daul, A.L., Li, M., Volk, M.L., Tennessen, J.M., Miller, E.A., Rougvie, A.E. Dev. Cell (2003) [Pubmed]

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