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Gene Review

Nmt2  -  N-myristoyltransferase 2

Mus musculus

Synonyms: A930001K02Rik, AI605445, AU044698, Glycylpeptide N-tetradecanoyltransferase 2, Myristoyl-CoA:protein N-myristoyltransferase 2, ...
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High impact information on Nmt2

  • The Nmt2 mRNA could be detected in Nmt1-/- ES cells, but the total NMT activity levels were reduced by approximately 95%, suggesting that Nmt2 contributes little to total enzyme activity levels in these early embryo cells [1].
  • Transient transfection of either the hNMT-1 or hNMT-2 cDNA into COS-7 cells resulted in the expression of high levels of NMT enzyme activity [2].
  • Western blot analyses revealed that loss of NMT2 shifted the expression of the BCL family of proteins toward apoptosis [3].

Other interactions of Nmt2

  • 5. Northern blots revealed lower levels of Nmt2 expression in early development than at later time points, a potential explanation for the demise of Nmt1-/- embryos [1].


  1. N-myristoyltransferase 1 is essential in early mouse development. Yang, S.H., Shrivastav, A., Kosinski, C., Sharma, R.K., Chen, M.H., Berthiaume, L.G., Peters, L.L., Chuang, P.T., Young, S.G., Bergo, M.O. J. Biol. Chem. (2005) [Pubmed]
  2. A second mammalian N-myristoyltransferase. Giang, D.K., Cravatt, B.F. J. Biol. Chem. (1998) [Pubmed]
  3. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Ducker, C.E., Upson, J.J., French, K.J., Smith, C.D. Mol. Cancer Res. (2005) [Pubmed]
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