Gene Review:
aco-1 - Protein ACO-1
Caenorhabditis elegans
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High impact information on aco-1
- We have shown that the expression levels of aco-1 and ftn-1 genes are both regulated by iron treatment but in opposite ways [1].
- Cytosolic aconitase (aco-1), iron regulatory protein, is known to regulate cellular iron concentration by modulating translation of the ferritin mRNA in addition to its enzymatic activity that converts citrate into iso-citrate [1].
- Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans [1].
References
- Transcriptional regulation and life-span modulation of cytosolic aconitase and ferritin genes in C.elegans. Kim, Y.I., Cho, J.H., Yoo, O.J., Ahnn, J. J. Mol. Biol. (2004) [Pubmed]
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