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Gene Review

aco-1  -  Protein ACO-1

Caenorhabditis elegans

 
 
 
 
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High impact information on aco-1

  • We have shown that the expression levels of aco-1 and ftn-1 genes are both regulated by iron treatment but in opposite ways [1].
  • Cytosolic aconitase (aco-1), iron regulatory protein, is known to regulate cellular iron concentration by modulating translation of the ferritin mRNA in addition to its enzymatic activity that converts citrate into iso-citrate [1].
  • Our results suggest that ftn-1 and aco-1 are transcriptionally regulated by iron and are important for iron homeostasis affecting life-span upon iron stress conditions in C.elegans [1].

References

 
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