The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Irp-1A  -  Iron regulatory protein 1A

Drosophila melanogaster

Synonyms: C-Acon, CG4900, Dmel\CG4900, IRP-1, IRP-1A, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Irp-1A

  • These results were also corroborated in whole-fly homogenates from transgenic flies that overexpress IRP-1A and IRP-1B in their fat bodies [1].
  • The Drosophila genome offers an evolutionary intermediate containing two IRP1-like proteins (IRP-1A and IRP-1B) and target genes with IREs [1].
  • Domain-swap experiments showed that multiple amino acid substitutions scattered throughout the IRP1 domains are synergistically required for conferring IRE binding activity [1].
  • In mammalian cells, iron homeostasis is largely regulated by post-transcriptional control of gene expression through the binding of iron-regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) contained in the untranslated regions of target mRNAs [1].
  • The strong labelling with low background revealed the localization of the BR 2.1 gene in polytene chromosome IV of C. tentans and the IRP1A gene in polytene chromosome 3R83 of D. melanogaster [2].
 

Anatomical context of Irp-1A

References

  1. Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein. Lind, M.I., Missirlis, F., Melefors, O., Uhrigshardt, H., Kirby, K., Phillips, J.P., Söderhäll, K., Rouault, T.A. J. Biol. Chem. (2006) [Pubmed]
  2. Using PRINS for gene mapping in polytene chromosomes. Gu, H.F., Lind, M.I., Wieslander, L., Landegren, U., Söderhäll, K., Melefors, O. Chromosome Res. (1997) [Pubmed]
 
WikiGenes - Universities