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ACO1  -  aconitate hydratase 1

Arabidopsis thaliana

Synonyms: F4B14.100, F4B14_100, aconitase 1
 
 
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Disease relevance of AT4G35830

 

High impact information on AT4G35830

  • We report the purification of the unstable aconitase enzyme from melon seeds and the NH2-terminal amino acid sequence determination [2].
  • Genomic clones of the aconitase gene were isolated, and comparison of the cDNA and genomic sequences reveals that the coding sequence is divided among 20 exons [2].
  • Structure, genomic organization, and expression of the Arabidopsis thaliana aconitase gene. Plant aconitase show significant homology with mammalian iron-responsive element-binding protein [2].
  • These damaged components included subunits of ATP synthase, complex I, succinyl CoA ligase, aconitase, and pyruvate and 2-oxoglutarate dehydrogenase complexes [3].
  • As copper but not aluminum selectively induces citrate production and release, it is proposed that copper may inhibit a cytosolic form of aconitase [4].

References

  1. Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana. Moeder, W., Del Pozo, O., Navarre, D.A., Martin, G.B., Klessig, D.F. Plant Mol. Biol. (2007) [Pubmed]
  2. Structure, genomic organization, and expression of the Arabidopsis thaliana aconitase gene. Plant aconitase show significant homology with mammalian iron-responsive element-binding protein. Peyret, P., Perez, P., Alric, M. J. Biol. Chem. (1995) [Pubmed]
  3. The impact of oxidative stress on Arabidopsis mitochondria. Sweetlove, L.J., Heazlewood, J.L., Herald, V., Holtzapffel, R., Day, D.A., Leaver, C.J., Millar, A.H. Plant J. (2002) [Pubmed]
  4. Early copper-induced leakage of K(+) from Arabidopsis seedlings is mediated by ion channels and coupled to citrate efflux. Murphy, A.S., Eisinger, W.R., Shaff, J.E., Kochian, L.V., Taiz, L. Plant Physiol. (1999) [Pubmed]
 
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