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Gene Review

Irp-1B  -  Iron regulatory protein 1B

Drosophila melanogaster

Synonyms: 144037_at, C-Acon, CG6342, Dmel\CG6342, IRP-1, ...
 
 
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High impact information on Irp-1B

  • Ubiquitous and muscle-specific overexpression of IRP-1A, but not of IRP-1B, resulted in pre-adult lethality, underscoring the importance of the biochemical difference between the two proteins [1].
  • The Drosophila genome offers an evolutionary intermediate containing two IRP1-like proteins (IRP-1A and IRP-1B) and target genes with IREs [1].
  • These results were also corroborated in whole-fly homogenates from transgenic flies that overexpress IRP-1A and IRP-1B in their fat bodies [1].
  • Domain-swap experiments showed that multiple amino acid substitutions scattered throughout the IRP1 domains are synergistically required for conferring IRE binding activity [1].
  • In mammalian cells, iron homeostasis is largely regulated by post-transcriptional control of gene expression through the binding of iron-regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) contained in the untranslated regions of target mRNAs [1].
 

Biological context of Irp-1B

  • We show that Drosophila iron regulatory protein-1 (IRP1) registers cytosolic iron and oxidative stress through its labile iron sulfur cluster by switching between cytosolic aconitase and RNA-binding functions [2].
 

Anatomical context of Irp-1B

 

Analytical, diagnostic and therapeutic context of Irp-1B

References

  1. Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein. Lind, M.I., Missirlis, F., Melefors, O., Uhrigshardt, H., Kirby, K., Phillips, J.P., Söderhäll, K., Rouault, T.A. J. Biol. Chem. (2006) [Pubmed]
  2. Compartment-specific protection of iron-sulfur proteins by superoxide dismutase. Missirlis, F., Hu, J., Kirby, K., Hilliker, A.J., Rouault, T.A., Phillips, J.P. J. Biol. Chem. (2003) [Pubmed]
  3. Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans. Muckenthaler, M., Gunkel, N., Frishman, D., Cyrklaff, A., Tomancak, P., Hentze, M.W. Eur. J. Biochem. (1998) [Pubmed]
 
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