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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ftt-2  -  Protein FTT-2

Caenorhabditis elegans

 
 
 
 
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High impact information on ftt-2

  • In contrast to ftt-2, RNAi knock down of par-5/ftt-1, the only other gene predicted to encode a 14-3-3 protein in C. elegans, did not show any notable effect on dauer formation, DAF-16 localization, or DAF-16 downstream gene transcription, underscoring the functional specification of FTT-2 and PAR-5 despite their high sequence homology [1].
  • We found that RNAi knock down of ftt-2 specifically enhanced the daf-2-mediated dauer formation phenotype [1].
  • The two genes, ftt-1 (IV) (fourteen-three-three) and ftt-2 (X), differ in both the position and sequence of their introns [2].
 

Other interactions of ftt-2

  • Furthermore, ftt-2 knock down caused the nuclear accumulation of DAF-16/FOXO, the forkhead transcription factor that is the major downstream effecter of daf-2/insulin-like signaling, and enhanced the transcriptional activities of DAF-16 [1].

References

  1. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Li, J., Tewari, M., Vidal, M., Sylvia Lee, S. Dev. Biol. (2007) [Pubmed]
  2. Expression patterns and transcript processing of ftt-1 and ftt-2, two C. elegans 14-3-3 homologues. Wang, W., Shakes, D.C. J. Mol. Biol. (1997) [Pubmed]
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