The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ftt-2  -  Protein FTT-2

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ftt-2

  • In contrast to ftt-2, RNAi knock down of par-5/ftt-1, the only other gene predicted to encode a 14-3-3 protein in C. elegans, did not show any notable effect on dauer formation, DAF-16 localization, or DAF-16 downstream gene transcription, underscoring the functional specification of FTT-2 and PAR-5 despite their high sequence homology [1].
  • We found that RNAi knock down of ftt-2 specifically enhanced the daf-2-mediated dauer formation phenotype [1].
  • The two genes, ftt-1 (IV) (fourteen-three-three) and ftt-2 (X), differ in both the position and sequence of their introns [2].

Other interactions of ftt-2

  • Furthermore, ftt-2 knock down caused the nuclear accumulation of DAF-16/FOXO, the forkhead transcription factor that is the major downstream effecter of daf-2/insulin-like signaling, and enhanced the transcriptional activities of DAF-16 [1].


  1. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Li, J., Tewari, M., Vidal, M., Sylvia Lee, S. Dev. Biol. (2007) [Pubmed]
  2. Expression patterns and transcript processing of ftt-1 and ftt-2, two C. elegans 14-3-3 homologues. Wang, W., Shakes, D.C. J. Mol. Biol. (1997) [Pubmed]
WikiGenes - Universities