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Gene Review

par-5  -  Protein PAR-5

Caenorhabditis elegans

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High impact information on par-5

  • In contrast to ftt-2, RNAi knock down of par-5/ftt-1, the only other gene predicted to encode a 14-3-3 protein in C. elegans, did not show any notable effect on dauer formation, DAF-16 localization, or DAF-16 downstream gene transcription, underscoring the functional specification of FTT-2 and PAR-5 despite their high sequence homology [1].
  • Furthermore, par-5 activity is required in the first cell cycle for the asymmetric cortical localization of PAR-1 and PAR-2 to the posterior, and PAR-3, PAR-6, and PKC-3 to the anterior [2].
  • We have shown by sequence analysis of par-5 mutants and by RNA interference that the par-5 gene is the same as the ftt-1 gene, and encodes a 14-3-3 protein [2].
  • We show that par-5 is required for asynchrony and asymmetry in the first embryonic cell divisions, normal pseudocleavage, normal cleavage spindle orientation at the two-cell stage, and localization of P granules and MEX-5 during the first and subsequent cell cycles [2].
  • Our analysis indicates that the par-5 14-3-3 gene plays a crucial role in the early events leading to polarization of the C. elegans zygote [2].

Biological context of par-5

  • The two genes, ftt-1 (IV) (fourteen-three-three) and ftt-2 (X), differ in both the position and sequence of their introns [3].

Anatomical context of par-5


  1. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Li, J., Tewari, M., Vidal, M., Sylvia Lee, S. Dev. Biol. (2007) [Pubmed]
  2. The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. Morton, D.G., Shakes, D.C., Nugent, S., Dichoso, D., Wang, W., Golden, A., Kemphues, K.J. Dev. Biol. (2002) [Pubmed]
  3. Expression patterns and transcript processing of ftt-1 and ftt-2, two C. elegans 14-3-3 homologues. Wang, W., Shakes, D.C. J. Mol. Biol. (1997) [Pubmed]
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