The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ywhaz  -  tyrosine 3-monooxygenase/tryptophan 5...

Mus musculus

Synonyms: 1110013I11Rik, 14-3-3 protein zeta/delta, 14-3-3 zeta, 14-3-3zeta, AI596267, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ywhaz

  • Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells [1].

High impact information on Ywhaz

  • Unlike ADP- or thrombin-induced PA, BL6 cell-induced PA was not inhibited by Calphostin-C (a potent protein kinase C inhibitor) or cilostazol (a potent inhibitor of PA based on inhibition of cyclic AMP phosphodiesterase) [2].
  • Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells [3].
  • The PGN-induced increase in kappaB luciferase activity was inhibited by NS398, AH6809, AH23848, KT5720, a protein kinase C inhibitor (Ro31-8220), and a p38 MAPK inhibitor (SB203580) [4].
  • Golgi kinase activity was strongly inhibited by the broad-range kinase inhibitor staurosporine and partially inhibited by the protein kinase C inhibitor bisindolylmaleimide I, but not by the other protein kinase A, Ca2+/calmodulin-dependent kinase II, myosin light chain kinase, and protein kinase G inhibitors tested [5].
  • Treatment of these cells with c-fos antisense DNA or protein kinase C inhibitor inhibited the stimulatory effect of glucose on LPL mRNA expression [6].

Biological context of Ywhaz


Anatomical context of Ywhaz


Associations of Ywhaz with chemical compounds

  • In the first, the effects of rIFN-gamma and rIL-1 alpha on cytoplasmic pH were measured in the presence of a protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, H-7 [13].
  • The potent protein kinase C inhibitor, H7, also inhibited IL-1-mediated responses, while HA1004, a weak inhibitor of protein kinase C, did not [14].
  • This phorbol 12,13-dibutyrate antagonism of N(2)O-induced antinociception was reversed by i.c.v. pretreatment with calphostin C, a protein kinase C inhibitor [15].
  • Similar to tenascin-C, immobilized antibody to GD2 (3F8) or sphingosine, a protein kinase C inhibitor, strongly inhibited RGD-dependent cell spreading [16].
  • We have previously shown that chronic (18 h) but not acute (30 min or 2 h) pretreatment with the muscarinic receptor agonist carbachol resulted in decreased adenylyl cyclase activity in response to GTP, isoproterenol, or forskolin via a pathway blocked by the protein kinase C inhibitor staurosporine [17].
  • In whole cell extracts from MN9D cells after 14-3-3 small interfering RNA treatments, we found that 14-3-3zeta knockdown significantly reduced TH activity and dopamine synthesis whereas knockdown of 14-3-3eta had no effect [18].

Other interactions of Ywhaz


  1. Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells. Ikegami, Y., Yano, S., Nakao, K. Jpn. J. Pharmacol. (1996) [Pubmed]
  2. Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. Okoshi, H., Hakomori, S., Nisar, M., Zhou, Q.H., Kimura, S., Tashiro, K., Igarashi, Y. Cancer Res. (1991) [Pubmed]
  3. Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells. Sako, T., Tauber, A.I., Jeng, A.Y., Yuspa, S.H., Blumberg, P.M. Cancer Res. (1988) [Pubmed]
  4. Peptidoglycan-induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2, PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B. Chen, B.C., Liao, C.C., Hsu, M.J., Liao, Y.T., Lin, C.C., Sheu, J.R., Lin, C.H. J. Immunol. (2006) [Pubmed]
  5. Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway. Lee, S.N., Hwang, J.R., Lindberg, I. J. Biol. Chem. (2006) [Pubmed]
  6. Stimulatory effect of glucose on macrophage lipoprotein lipase expression and production. Sartippour, M.R., Lambert, A., Laframboise, M., St-Jacques, P., Renier, G. Diabetes (1998) [Pubmed]
  7. Expression of stage-specific genes during zygotic gene activation in preimplantation mouse embryos. Li, W., Zhang, J., Yu, W., Liu, G., Chen, Q. Zool. Sci. (2003) [Pubmed]
  8. Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells. Rao, P., Kitamura, T., Miyajima, A., Mufson, R.A. J. Immunol. (1995) [Pubmed]
  9. Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium. Bigby, M., Wang, P., Fierro, J.F., Sy, M.S. J. Immunol. (1990) [Pubmed]
  10. Enhanced gene expression of the murine ecotropic retroviral receptor and its human homolog in proliferating cells. Yoshimoto, T., Yoshimoto, E., Meruelo, D. J. Virol. (1992) [Pubmed]
  11. Staurosporine induces tyrosine phosphorylation of a 145 kDa protein but does not activate gp140trk in PC12 cells. Rasouly, D., Lazarovici, P. Eur. J. Pharmacol. (1994) [Pubmed]
  12. CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway. Kasinrerk, W., Tokrasinwit, N., Moonsom, S., Stockinger, H. Immunol. Lett. (2000) [Pubmed]
  13. Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization. Ostrowski, J., Meier, K.E., Stanton, T.H., Smith, L.L., Bomsztyk, K. J. Biol. Chem. (1988) [Pubmed]
  14. Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction. Gottlieb, R.A., Lennarz, W.J., Knowles, R.D., Cianciolo, G.J., Dinarello, C.A., Lachman, L.B., Kleinerman, E.S. J. Immunol. (1989) [Pubmed]
  15. Involvement of brain protein kinase C in nitrous oxide-induced antinociception in mice. Ishikawa, M., Matsushita, Y., Abe, K., Utsunomiya, I., Hoshi, K., Quock, R.M., Taguchi, K. Neuroscience (2006) [Pubmed]
  16. Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism. Probstmeier, R., Pesheva, P. Glycobiology (1999) [Pubmed]
  17. Decreased adenylyl cyclase protein and function in airway smooth muscle by chronic carbachol pretreatment. Emala, C.W., Clancy-Keen, J., Hirshman, C.A. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  18. 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria. Wang, J., Lou, H., Pedersen, C.J., Smith, A.D., Perez, R.G. J. Biol. Chem. (2009) [Pubmed]
WikiGenes - Universities