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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

akt-2  -  Protein AKT-2

Caenorhabditis elegans

 
 
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High impact information on akt-2

  • This demonstrates that Akt/PKB activity is not necessarily dependent on AGE-1 PI3K activity. akt-1 and akt-2 are expressed in overlapping patterns in the nervous system and in tissues that are remodeled during dauer formation [1].
  • In mammals, AKT/PKB regulates cell survival by modulating the activity of several apoptotic proteins, including p53 . In Caenorhabditis elegans, akt-1 and akt-2 regulate development in response to environmental cues by controlling the FOXO transcription factor daf-16, but the role of these genes in regulating p53-dependent apoptosis is not known [2].
  • In this study, we show that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline [2].

References

  1. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Paradis, S., Ruvkun, G. Genes Dev. (1998) [Pubmed]
  2. AKT-1 Regulates DNA-Damage-Induced Germline Apoptosis in C. elegans. Quevedo, C., Kaplan, D.R., Derry, W.B. Curr. Biol. (2007) [Pubmed]
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