The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Nthl1  -  nth (endonuclease III)-like 1 (E.coli)

Mus musculus

Synonyms: Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase, DNA glycoslyase/AP lyase, Endonuclease III-like protein 1, Nth1, Octs3
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Nthl1

 

High impact information on Nthl1

  • Thus, this previously undescribed, and hence novel, back-up enzyme activity may function to repair oxidized 5meCyt residues in DNA while also being sufficient to compensate for the loss of Nth1 in the mutant mice, thereby explaining the noninformative phenotype [1].
  • Identification of functional elements in the bidirectional promoter of the mouse Nthl1 and Tsc2 genes [2].
 

Biological context of Nthl1

  • We found that the short spacer sequence of 63 base pairs (bp) between the mouse Nthl1 and Tsc2 genes shows bidirectional promoter activity essential for the transcription of both genes [2].
 

Associations of Nthl1 with chemical compounds

References

  1. Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity. Ocampo, M.T., Chaung, W., Marenstein, D.R., Chan, M.K., Altamirano, A., Basu, A.K., Boorstein, R.J., Cunningham, R.P., Teebor, G.W. Mol. Cell. Biol. (2002) [Pubmed]
  2. Identification of functional elements in the bidirectional promoter of the mouse Nthl1 and Tsc2 genes. Ikeda, S., Mochizuki, A., Sarker, A.H., Seki, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  3. Relations between clusters of oxidatively damaged nucleotides and active or open nucleosomes in the rat Nth 1 gene. Nomoto, M., Yamaguchi, R., Kohno, K., Kasai, H. Oncogene (2002) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities