Gene Review:
Tsc2 - tuberous sclerosis 2
Mus musculus
Synonyms:
Nafld, Tcs2, Tuberin, Tuberous sclerosis 2 protein homolog, tuberin
- A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Kwiatkowski, D.J., Zhang, H., Bandura, J.L., Heiberger, K.M., Glogauer, M., el-Hashemite, N., Onda, H. Hum. Mol. Genet. (2002)
- Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Kobayashi, T., Minowa, O., Kuno, J., Mitani, H., Hino, O., Noda, T. Cancer Res. (1999)
- Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery. Brown, A.B., Mahmood, U., Cortes, M.L., Tang, Y., Dai, G., Stemmer-Rachamimov, A., Prabhakar, S., Leishear, K., Onda, H., Kwiatkowski, D., Weissleder, R., Breakefield, X. Hum. Gene Ther. (2005)
- Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain. Govindarajan, B., Brat, D.J., Csete, M., Martin, W.D., Murad, E., Litani, K., Cohen, C., Cerimele, F., Nunnelley, M., Lefkove, B., Yamamoto, T., Lee, C., Arbiser, J.L. J. Biol. Chem. (2005)
- Learning, memory, and transcription factors. Johnston, M.V., Alemi, L., Harum, K.H. Pediatr. Res. (2003)
- Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Manning, B.D., Tee, A.R., Logsdon, M.N., Blenis, J., Cantley, L.C. Mol. Cell (2002)
- Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. Onda, H., Lueck, A., Marks, P.W., Warren, H.B., Kwiatkowski, D.J. J. Clin. Invest. (1999)
- The NF1 tumor suppressor critically regulates TSC2 and mTOR. Johannessen, C.M., Reczek, E.E., James, M.F., Brems, H., Legius, E., Cichowski, K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells. Uhlmann, E.J., Apicelli, A.J., Baldwin, R.L., Burke, S.P., Bajenaru, M.L., Onda, H., Kwiatkowski, D., Gutmann, D.H. Oncogene (2002)
- The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene. Olsson, P.G., Löhning, C., Horsley, S., Kearney, L., Harris, P.C., Frischauf, A. Genomics (1996)
- Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development. Rennebeck, G., Kleymenova, E.V., Anderson, R., Yeung, R.S., Artzt, K., Walker, C.L. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex. Kawakami, S., Mitsunaga, K., Kikuti, Y.Y., Ando, A., Inoko, H., Yamamura, K., Abe, K. Mamm. Genome (1998)
- Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment. El-Hashemite, N., Zhang, H., Walker, V., Hoffmeister, K.M., Kwiatkowski, D.J. Cancer Res. (2004)
- Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway. Jiang, X., Yeung, R.S. Cancer Res. (2006)
- Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. van Slegtenhorst, M., Carr, E., Stoyanova, R., Kruger, W.D., Henske, E.P. J. Biol. Chem. (2004)
- Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis. Aicher, L.D., Campbell, J.S., Yeung, R.S. J. Biol. Chem. (2001)
- Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. Xu, L., Sterner, C., Maheshwar, M.M., Wilson, P.J., Nellist, M., Short, P.M., Haines, J.L., Sampson, J.R., Ramesh, V. Genomics (1995)
- Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. Plas, D.R., Thompson, C.B. J. Biol. Chem. (2003)
- Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome. Simckes, A.M., Swanson, S.K., White, R.A. Cytogenet. Genome Res. (2002)
- Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. El-Hashemite, N., Walker, V., Zhang, H., Kwiatkowski, D.J. Cancer Res. (2003)
- Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. Williamson, D.L., Kubica, N., Kimball, S.R., Jefferson, L.S. J. Physiol. (Lond.) (2006)
- Identification of functional elements in the bidirectional promoter of the mouse Nthl1 and Tsc2 genes. Ikeda, S., Mochizuki, A., Sarker, A.H., Seki, S. Biochem. Biophys. Res. Commun. (2000)
- A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. Sale, E.M., Hodgkinson, C.P., Jones, N.P., Sale, G.J. Biochemistry (2006)
- Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III. Sarker, A.H., Ikeda, S., Nakano, H., Terato, H., Ide, H., Imai, K., Akiyama, K., Tsutsui, K., Bo, Z., Kubo, K., Yamamoto, K., Yasui, A., Yoshida, M.C., Seki, S. J. Mol. Biol. (1998)