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Gene Review

ser-2  -  Protein SER-2

Caenorhabditis elegans

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High impact information on ser-2

  • Lastly, we analyze a mutant allele of the ser-2 tyramine receptor, a target of the ttx-3 Lhx gene in the AIY interneuron class. ser-2 mutants display none of the defects previously shown to be associated with loss of AIY function [1].
  • Moreover, we describe distinct but partially overlapping expression patterns of different splice forms of the ser-2 tyramine receptor locus [1].
  • Most importantly, ser-2 null mutants (pk1357) fail to suppress head movements while reversing in response to nose-touch, suggesting a role for SER-2 in the regulation of foraging behavior, and fail to respond to tyramine in assays measuring serotonin-dependent pharyngeal pumping [2].
  • We have isolated two cDNAs, ser-2 and ser-2a, encoding putative C.elegans serotonin/OA receptors (C02D4.2, ser-2) [3].


  1. LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. Tsalik, E.L., Niacaris, T., Wenick, A.S., Pau, K., Avery, L., Hobert, O. Dev. Biol. (2003) [Pubmed]
  2. Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans. Rex, E., Molitor, S.C., Hapiak, V., Xiao, H., Henderson, M., Komuniecki, R. J. Neurochem. (2004) [Pubmed]
  3. Characterization of a tyramine receptor from Caenorhabditis elegans. Rex, E., Komuniecki, R.W. J. Neurochem. (2002) [Pubmed]
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