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Gene Review

Nup62  -  nucleoporin 62

Mus musculus

Synonyms: 62 kDa nucleoporin, AA589433, AI426861, AI790512, AU045898, ...
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High impact information on Nup62


Biological context of Nup62

  • The antibodies described in this study provide the means for immunochemical analyses of the NPC protein Nup62/p62 in mammalian cells, and represent useful molecular tools that should permit a better understanding of the biological roles and cellular dynamics of this protein in nucleocytoplasmic transport, cell division, and nuclear organization [3].

Analytical, diagnostic and therapeutic context of Nup62

  • Western blotting of total brain homogenates, using the same antibody, shows a p39 band in control rats which is accompanied by a strong, phosphorylated p62 double-band in irradiated animals [4].


  1. Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action. Arakane, F., Sugawara, T., Nishino, H., Liu, Z., Holt, J.A., Pain, D., Stocco, D.M., Miller, W.L., Strauss, J.F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Steroidogenic acute regulatory protein binds cholesterol and modulates mitochondrial membrane sterol domain dynamics. Petrescu, A.D., Gallegos, A.M., Okamura, Y., Strauss, J.F., Schroeder, F. J. Biol. Chem. (2001) [Pubmed]
  3. Functional analysis of nuclear pore complex protein Nup62/p62 using monoclonal antibodies. Fukuhara, T., Sakaguchi, N., Katahira, J., Yoneda, Y., Ogino, K., Tachibana, T. Hybridoma (2005) (2006) [Pubmed]
  4. Radiation-induced apoptosis in developing rats and kainic acid-induced excitotoxicity in adult rats are associated with distinctive morphological and biochemical c-Jun/AP-1 (N) expression. Ferrer, I., Planas, A.M., Pozas, E. Neuroscience (1997) [Pubmed]
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