Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

oh - obstructive hydrocephalus

Mus musculus

Crews, L. et al., Tullio, A.N. et al., Sakakibara, S. et al., Bloch, O. et al.

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Disease relevance of oh

By E18.5 and P0, the defects in cells lining the ventricular wall resulted in an obstructive hydrocephalus due to stenosis or occlusion of the third ventricle and cerebral aqueduct [1].

High impact information on oh

Homozygous newborn mice frequently developed obstructive hydrocephalus with aberrant proliferation of ependymal cells in a restricted area surrounding the Sylvius aqueduct [2].
Although the causes of obstructive hydrocephalus are better understood, the mechanisms resulting in chronic, progressive communicating congenital and acquired hydrocephalus are less well understood [3].
A mouse model of obstructive hydrocephalus was created by injecting kaolin (2.5 mg/mouse) into the cisterna magna [4].

References

Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. Tullio, A.N., Bridgman, P.C., Tresser, N.J., Chan, C.C., Conti, M.A., Adelstein, R.S., Hara, Y. J. Comp. Neurol. (2001) [Pubmed]
RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Sakakibara, S., Nakamura, Y., Yoshida, T., Shibata, S., Koike, M., Takano, H., Ueda, S., Uchiyama, Y., Noda, T., Okano, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Crews, L., Wyss-Coray, T., Masliah, E. Brain Pathol. (2004) [Pubmed]
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. Bloch, O., Auguste, K.I., Manley, G.T., Verkman, A.S. J. Cereb. Blood Flow Metab. (2006) [Pubmed]

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