Disease relevance of Cerebral Aqueduct

• Type 1b were associated with hydrocephalus secondary to diencephalic malformations prohibiting egress of CSF from the third ventricle into the aqueduct of Sylvius [1].
• X linked complicated spastic paraplegia, MASA syndrome, and X linked hydrocephalus owing to congenital stenosis of the aqueduct of Sylvius: variable expression of the same mutation at Xq28 [2].
• There was no decrease in lumbar CSF cAMP in patients with a complete stenosis of the aqueduct of Sylvius, partial blocks of CSF flow at the cervical level, or a complete block at the lower thoracic level [3].

Psychiatry related information on Cerebral Aqueduct

• The increase in locomotor activity from injections of CRF into the cisterna magna was blocked by a cold cream plug in the cerebral aqueduct [4].

High impact information on Cerebral Aqueduct

• Homozygous newborn mice frequently developed obstructive hydrocephalus with aberrant proliferation of ependymal cells in a restricted area surrounding the Sylvius aqueduct [5].
• To control for this, we occluded the cerebral aqueduct to restrict CSF flow between the forebrain and CBS ventricles and tested all combinations (same and cross ventricle) of ghrelin (150 pmol/1 microl) and NPY receptor antagonist delivery [6].
• In the H-Tx rat, obstruction and eventual blockage of CSF flow occurs in the cerebral aqueduct, between the third and fourth ventricles, at embryonic day 18 [7].
• The most important features of homozygous mutants that we observed were the absence or malformation of the posterior commissure (PC) and of the subcommissural organ (SCO), the collapse of the cerebral aqueduct, and the development of hydrocephalus [8].
• After administration of 10 micrograms neuraminidase, ciliated cuboidal ependymal cells of the lateral ventricles, third ventricle, cerebral aqueduct, and the rostral half of the fourth ventricle died and detached [9].

Biological context of Cerebral Aqueduct

• Bilateral lesions of the ventrolateral medulla near the rostral lateral border of the inferior olivary tract nuclei (P12.0, LR 2.0, HD -10 mm) also attenuated the muscle pressor response, while subsequent injections of clonidine into the cerebral aqueduct depressed the changes in blood pressure further [10].
• Clonidine was injected into the cerebral aqueduct to determine whether it would exert an antipressor effect during muscle contraction after the lesions were made [10].
• Resting arterial pressure, heart rate and bilateral carotid occlusion response were not affected when the distribution of 5-HTP was confined to neural structures rostral to the midcollicular level by injection into the third or lateral cerebral ventricle with the cerebral aqueduct cannulated for drainage [11].
• PGE2 was infused into the cerebral aqueduct and sexual behavior and hypothalamic temperature were monitored [12].
• Pentobarbital and magnesium chloride elicited an increase in body temperature when injected into the third ventricle but not when injected into the cerebral aqueduct [13].

Anatomical context of Cerebral Aqueduct

• Autoradiographic studies indicated that a 2-nmol, intraventricular dose of DAMGO achieved contents greater than 1 pmol/mg in tissue lying within 2 mm of the lateral ventricle, third ventricle and cerebral aqueduct [14].
• Progestin receptor-immunoreactive cells were far fewer than estrogen receptor containing cells, had less cytoplasmic staining, and appeared restricted to the midbrain central gray, lateral and ventrolateral to the cerebral aqueduct and the adjacent tegmental area [15].

Associations of Cerebral Aqueduct with chemical compounds

• Injections of clonidine into the cerebral aqueduct had no further antipressor effects after the lesions [10].
• Previous studies have shown that nicotinic receptors (NAChRs) accessible from the cerebral aqueduct of the brainstem mediate the hippocampal norepinephrine (NE) release induced by i.v. nicotine [16].
• At the time of birth, hydrocephalic animals showed an abnormality in the distribution of high-affinity melatonin receptors dorsal to the cerebral aqueduct when compared to controls [17].
• Both i.c.v. infusion and repeated bolus injections into the cerebral aqueduct of an antisense oligonucleotide against the alpha4 subunit significantly attenuated the antinociceptive effects of the nAChR agonist A-85380 in the paw withdrawal test of acute thermal pain [18].
• Pentobarbital, barbital, calcium chloride, and magnesium chloride elicited feeding in sheep when injected into the third ventricle or into the cerebral aqueduct; however, feeding response was less after injections into the latter [13].

Gene context of Cerebral Aqueduct

• Nestin and vimentin were also expressed in immature ependymal cells or their basal processes in anatomical regions such as the roof or floor plate of the fourth ventricle or the cerebral aqueduct, and the ventral part of the third ventricle [19].
• Hydrocephalic hyh mice are born with moderate hydrocephalus and a normal cerebral aqueduct [20].
• Here, we report that ventricular dilation in L1-deficient mice is not correlated with stenosis of the aqueduct of Sylvius nor with ultrastructural abnormalities of ependymal cells lining the lateral ventricles or the aqueduct [21].
• Normal position of the aqueduct of Sylvius. Part 2: evaluation of two preaqueductal proportional methods [22].
• Plugging of the cerebral aqueduct with cold cream fails to prevent grooming in response to lateral ventricle injection of ACTH [23].

Analytical, diagnostic and therapeutic context of Cerebral Aqueduct

• METHODS: In chloralose anaesthetized cats, the aqueduct of Sylvius was cannulated so that the outflow end of the plastic cannula was positioned extracranially [24].

References