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MeSH Review

Cisterna Magna

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Disease relevance of Cisterna Magna


High impact information on Cisterna Magna

  • We found that injection of recombinant human TNF into the cisterna magna in the rabbit led to an acute reduction in cerebral oxygen uptake and a more prolonged reduction in cerebral blood flow [6].
  • Exposure to N-ethyl-N-nitrosourea (ENU) either transplacentally via the maternal bloodstream or postnatally by direct injection into the cerebellum or the cisterna magna resulted in a high incidence of spinal tumors in an inbred strain of W albino rats [7].
  • EDN, ECP-1, and ECP-2 had neurotoxic activity, causing the Gordon phenomenon at doses down to 0.15 micrograms when injected into the cisterna magna; the proteins were comparable in their activities [8].
  • After the administration of 1 ml lipo-BCNU (BCNU, 4.67 mM) or 1 ml BCNU solubilized with 5% dextrose/water (BCNU, 4.67 mM) into the cisterna magna of dogs, the cisterna magna cerebrospinal fluid was sampled, and the BCNU concentrations were assayed by high-performance liquid chromatography [9].
  • CSF pressure recordings have been taken from the lumbar region and the cisterna magna of 16 patients during coughing in the sitting position [10].

Chemical compound and disease context of Cisterna Magna


Biological context of Cisterna Magna


Anatomical context of Cisterna Magna


Associations of Cisterna Magna with chemical compounds

  • Peak cisterna magna CSF lactate concentrations 10 to 30 minutes into recovery distinguished those animals that remained brain-intact (less than 13 mM) from those that developed brain damage (greater than 15 mM) with 100% accuracy [26].
  • Endogenous CSF samples were taken from the cisterna magna of pentobarbital-anesthetized mongrel dogs (n = 11) and were shown to contain 13 +/- 3 pg/ml (mean +/- SE) of immunoreactive kinin ( ikinin ) measured by RIA [27].
  • In these experiments only a small fraction of the radioactive PGF2alpha injected into the cisterna magna appeared in lumbar CSF [28].
  • The concentration of penicillin G in the perfusate, collected from the cisterna magna, was 76.5 percent +/- 1.0 (SEM) of that entering the ventricles (having adjusted for normal secretion of CSF) [29].
  • METHODS: Glibenclamide (19.8 microg) or vehicle was injected into the cisterna magna of barbiturate-anesthetized rats [30].

Gene context of Cisterna Magna

  • Immunocytochemistry for HO-1, HO-2 and HSP70 proteins was performed at 1, 2, 3 and 4 days after injections of lysed blood, whole blood, oxyhemoglobin and saline into the cisterna magna [31].
  • The present study evaluates the dynamics of ET-1 concentration changes in the plasma of rats in the acute phase of vasospasm after SAH, which was induced by administering 100 microliters non-heparinized fresh autologous arterial blood into the brain cisterna magna (CM) [32].
  • Injection of synthetic rat galanin (12.5-50 pmol/rat) into the cisterna magna (i.c.s.) suppressed plasma AVP increased by polyethylene glycol-induced hypovolemia (2.45 +/- 0.24 pg/ml at 50 pmol/rat vs. the vehicle group 5.72 +/- 0.69 pg/ml, p < 0.01) [33].
  • CSF was collected from a cannula inserted into the cisterna magna, and was frozen until the tissue kallikrein in the samples was measured by radioimmunoassay [34].
  • Administration of thiorphan , an enkephalin dipeptidyl carboxypeptidase inhibitor, did not potentiate the analgesic effect of D- Arg2 -Met5-enkephalin, whereas it dramatically enhanced the effect of D-Ala2-Met5-enkephalin, when both drugs were administered concomitantly into the cisterna magna of mice [35].

Analytical, diagnostic and therapeutic context of Cisterna Magna


  1. Targeted therapy with immunotoxins in a nude rat model for leptomeningeal growth of human small cell lung cancer. Myklebust, A.T., Godal, A., Fodstad, O. Cancer Res. (1994) [Pubmed]
  2. Increased brain interstitial fluid adenosine concentration during hypoxia in newborn piglet. Park, T.S., Van Wylen, D.G., Rubio, R., Berne, R.M. J. Cereb. Blood Flow Metab. (1987) [Pubmed]
  3. Attenuation of progressive brain hypoperfusion following experimental subarachnoid hemorrhage by large intravenous doses of methylprednisolone. Hall, E.D., Travis, M.A. Exp. Neurol. (1988) [Pubmed]
  4. Respiratory depression produced by glycine injected into the cisterna magna of cats. Holtman, J.R., Buller, A.L., Hamosh, P., Da Silva, A.M., Gillis, R.A. Neuropharmacology (1982) [Pubmed]
  5. Opposing effects of isoflurane and sevoflurane on neurogenic pulmonary edema development in an animal model. Kandatsu, N., Nan, Y.S., Feng, G.G., Nishiwaki, K., Hirokawa, M., Ishikawa, K., Komatsu, T., Yokochi, T., Shimada, Y., Ishikawa, N. Anesthesiology (2005) [Pubmed]
  6. Effect of recombinant human tumor necrosis factor-alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: role of nitric oxide. Tureen, J. J. Clin. Invest. (1995) [Pubmed]
  7. N-ethyl-N-nitrosourea-induced spinal tumors in an inbred strain of W albino rats. Pfaffenroth, M.J., Das, G.D. J. Natl. Cancer Inst. (1979) [Pubmed]
  8. Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease. Gleich, G.J., Loegering, D.A., Bell, M.P., Checkel, J.L., Ackerman, S.J., McKean, D.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  9. Intrathecal chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea encapsulated into hybrid liposomes for meningeal gliomatosis: an experimental study. Kitamura, I., Kochi, M., Matsumoto, Y., Ueoka, R., Kuratsu, J., Ushio, Y. Cancer Res. (1996) [Pubmed]
  10. Cerebrospinal fluid pressure changes in response to coughing. Williams, B. Brain (1976) [Pubmed]
  11. Central autonomic activation by intracisternal TRH analogue excites gastric splanchnic afferent neurons. Adelson, D.W., Wei, J.Y., Yashar, M., O-Lee, T.J., Taché, Y. J. Neurophysiol. (1999) [Pubmed]
  12. Scanning electron microscopy of the subarachnoid space in the dog. V. Macrophages challenged by bacillus Calmette-Guerin. Merchant, R.E., Low, F.N. J. Comp. Neurol. (1977) [Pubmed]
  13. Effects of chlorpromazine on experimental delayed cerebral vasospasm. Nakano, M., Tani, E., Fukumori, T., Yokota, M. J. Neurosurg. (1984) [Pubmed]
  14. Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats. Jośko, J. Brain Res. (2003) [Pubmed]
  15. Intracisternal DIDS enhances ventilatory response to rebreathing CO2 in rats. Adams, J.M., Johnson, N.L. J. Appl. Physiol. (1988) [Pubmed]
  16. Enkephalin effects on blood pressure, heart rate, and baroreceptor reflex. Schaz, K., Stock, G., Simon, W., Schlör, K.H., Unger, T., Rockhold, R., Ganten, D. Hypertension (1980) [Pubmed]
  17. Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. Ivanov, A., Gerzanich, V., Ivanova, S., Denhaese, R., Tsymbalyuk, O., Simard, J.M. J. Physiol. (Lond.) (2006) [Pubmed]
  18. Brainstem mechanisms in the modulation of the sympathetic baroreflex by piperoxan. Laubie, M., Schmitt, H. Eur. J. Pharmacol. (1988) [Pubmed]
  19. Regional vasoconstriction and excessive grooming induced by L-arginine injection into the cisterna magna of conscious rats. Takemoto, Y. Jpn. J. Physiol. (1993) [Pubmed]
  20. The effect of metrizamide on regional brain glucose metabolism in the rat. Bech, L., Diemer, N.H., Gjedde, A. Acta neurologica Scandinavica. (1984) [Pubmed]
  21. Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination. Furlan, R., Poliani, P.L., Galbiati, F., Bergami, A., Grimaldi, L.M., Comi, G., Adorini, L., Martino, G. Hum. Gene Ther. (1998) [Pubmed]
  22. Role of nitric oxide in the cerebral vasodilatory responses to vasopressin and oxytocin in dogs. Oyama, H., Suzuki, Y., Satoh, S., Kajita, Y., Takayasu, M., Shibuya, M., Sugita, K. J. Cereb. Blood Flow Metab. (1993) [Pubmed]
  23. Effect of urapidil, clonidine, and prazosin on sympathetic tone in conscious rats. Luft, F.C., Veelken, R., Becker, H., Ganten, D., Lang, R.E., Unger, T. Hypertension (1986) [Pubmed]
  24. Cerebellar atrophy demonstrated by computed tomography. Koller, W.C., Glatt, S.L., Perlik, S., Huckman, M.S., Fox, J.H. Neurology (1981) [Pubmed]
  25. Imidazoleacetic acid, a gamma-aminobutyric acid receptor agonist, can be formed in rat brain by oxidation of histamine. Thomas, B., Prell, G.D. J. Neurochem. (1995) [Pubmed]
  26. Brain injury from marked hypoxia in cats: role of hypotension and hyperglycemia. de Courten-Myers, G.M., Yamaguchi, S., Wagner, K.R., Ting, P., Myers, R.E. Stroke (1985) [Pubmed]
  27. Cerebrospinal fluid kinins and cardiovascular function. Effects of cerebroventricular melittin. Thomas, G.R., Thibodeaux, H., Margolius, H.S., Privitera, P.J. Hypertension (1984) [Pubmed]
  28. Levels and disappearance of prostaglandin F2alpha in cerebral spinal fluid: a clinical and experimental study. Hagen, A.A., Gerber, J.N., Sweeley, C.C., White, R.P., Robertson, J.T. Stroke (1977) [Pubmed]
  29. Penicillin transport from cerebrospinal fluid. Walters, I.N., Teychenne, P.F., Claveria, L.E., Calne, D.B. Neurology (1976) [Pubmed]
  30. Cerebral blood flow during hemodilution and hypoxia in rats : role of ATP-sensitive potassium channels. Tomiyama, Y., Brian, J.E., Todd, M.M. Stroke (1999) [Pubmed]
  31. Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Matz, P., Turner, C., Weinstein, P.R., Massa, S.M., Panter, S.S., Sharp, F.R. Brain Res. (1996) [Pubmed]
  32. Influence endothelin ETA receptor antagonist--BQ-123--on changes of endothelin-1 level in plasma of rats with acute vasospasm following subarachnoid hemorrhage. Jośko, J., Hendryk, S., Jedrzejowska-Szypuła, H., Gwóźdź, B., Herman, Z.S., Gawlik, R. J. Physiol. Pharmacol. (1998) [Pubmed]
  33. Galanin as a physiological neurotransmitter in hemodynamic control of arginine vasopressin release in rats. Kondo, K., Murase, T., Otake, K., Ito, M., Kurimoto, F., Oiso, Y. Neuroendocrinology (1993) [Pubmed]
  34. Cerebrospinal fluid kallikrein in spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats. Khan, I.M., Yamaji, I., Miller, D.H., Margolius, H.S., Privitera, P.J. J. Hypertens. (1993) [Pubmed]
  35. Opioid activity of enkephalin analogues containing the kyotorphin-related structure in the N-terminus. Amano, H., Morimoto, Y., Kaneko, S., Takagi, H. Neuropharmacology (1984) [Pubmed]
  36. Release of E prostaglandins into the cerebrospinal fluid and its inhibition by melatonin after cervical stimulation in the rabbit. Leach, C.M., Reynoldson, J.A., Thorburn, G.D. Endocrinology (1982) [Pubmed]
  37. Expression of c-fos-like immunoreactivity in brainstem after meningeal irritation by blood in the subarachnoid space. Nozaki, K., Boccalini, P., Moskowitz, M.A. Neuroscience (1992) [Pubmed]
  38. Release of beta-endorphin immunoreactivity into ventriculo-cisternal perfusate by lumbar intrathecal capsaicin in the rat. Bach, F.W., Yaksh, T.L. Brain Res. (1995) [Pubmed]
  39. Mega cisterna magna: diagnosis using metrizamide computed tomographic cisternography. Hough, D.R., Mengel, M.B., Malik, A.H. Neurosurgery (1982) [Pubmed]
  40. Microdialysis analysis of effects of loop diuretics and acetazolamide on chloride transport from blood to CSF. Johanson, C.E., Palm, D.E., Dyas, M.L., Knuckey, N.W. Brain Res. (1994) [Pubmed]
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