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MeSH Review

Third Ventricle

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Disease relevance of Third Ventricle


Psychiatry related information on Third Ventricle


High impact information on Third Ventricle


Chemical compound and disease context of Third Ventricle


Biological context of Third Ventricle


Anatomical context of Third Ventricle

  • In brain, approximately 80% of T3 is formed locally from T4 through the activity of the 5'-deiodinase type 2 (D2), an enzyme that is expressed mostly by glial cells, tanycytes in the third ventricle, and astrocytes throughout the brain [25].
  • Conversely, GK message was not found in the nucleus tractus solitarius, which contains glucosensing neurons, or in ependymal cells lining the third ventricle, where others have described its presence [26].
  • Both sites of 6-OH-dopamine administration markedly deplete hypothalamic dopamine and norepinephrine, but injection of 6-OH-dopamine into the lateral ventricle destroys the catecholaminergic terminals in the pineal, whereas injection of 6-OH-dopamine into the third ventricle does not [27].
  • Neurons expressing both TH and PR were detected in the rostral hypothalamus, lateral to the third ventricle (A11-rostral) and in a discrete subventricular population (A11-subvent) [28].
  • These experiments tested this hypothesis by examining the effects of progesterone on dynorphin A concentrations in cerebrospinal fluid (CSF) collected from the third ventricle and expression of preprodynorphin (PPD) mRNA in hypothalamic nuclei [29].

Associations of Third Ventricle with chemical compounds

  • Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice [30].
  • Infusions of [3H]alpha-bungarotoxin alone or preceded by tubocurarine or atropine were given into the third ventricle [31].
  • The area of the third ventricle in its most anterior coronal slice was increased by 73% in schizophrenic subjects (0.83 +/- 0.08 cm2) in comparison with controls (0.48 +/- 0.04 cm2) [32].
  • Injection into the third ventricle of either 1 or 3 microliter of neurotensin antiserum significantly increased plasma prolactin concentrations in (i) ovariectomized and (ii) ovariectomized estrogen- and progesterone-primed rats within 1 hr of injection [33].
  • AH 6809 in saline was infused continuously into the third ventricle of freely moving rats at a rate of 2.1, 6.3, and 21 pmol/min from 2300 to 0500 hr [34].

Gene context of Third Ventricle

  • In females more than in males, a significantly larger number of ERbeta mRNA-positive cells were visualized in the medial-most portion of the AVPV within 50 microm from the ependymal lining of the third ventricle [20].
  • When 3 micrograms VIP were injected into the third ventricle of conscious ovariectomized rats, a significant (P less than 0.005) and transient elevation of plasma oxytocin (OT) levels was observed [35].
  • Anti-Abeta antibody was injected into the third ventricle (icv) of 10-month-old Tg2576 mice, preceding formation of plaques [36].
  • Here we show the administration of IL-1 and IL-6 into the third ventricle increased MT-I+II protein levels in specific brain areas in the rat [37].
  • One injection of 10 microg of anti-Abeta antibody into the third ventricle at 10 months completely prevented or restored changes in GFAP at 11 months of age [36].

Analytical, diagnostic and therapeutic context of Third Ventricle

  • To test this hypothesis, we pretreated rats with a selective and potent GLP-1 receptor antagonist given directly into the third ventricle via an indwelling cannula before administration of peripheral LiCl [38].
  • The increase in GAD activity induced by intraventricular injection of 5-HT was completely blocked by injecting an antiserum against cAMP into the third ventricle 30 min earlier, whereas an injection of serum from normal rabbits was ineffective [39].
  • By in situ hybridization, the increased D2 mRNA synthesis induced by LPS was specifically localized to tanycytes lining the third ventricle [40].
  • In the first series, clonidine (1 mug/kg) was administered directly into the third ventricle of a group of dogs in which renal perfusion pressure was controlled by adjusting an aortic clamp [41].
  • A supraependymal cluster of neuronal cells and processes consistently present on the floor of the hamster third ventricle was identified and characterized by means of correlative scanning (SEM) and transmission (TEM) electron microscopy [42].


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  12. Paradoxical elevation of growth hormone by intraventricular somatostatin: possible ultrashort-loop feedback. Lumpkin, M.D., Gegro-Vilar, A., McCann, S.M. Science (1981) [Pubmed]
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  16. Participation of arginine vasopressin-mediated and adrenergic system-mediated mechanisms in the hypertension induced by intracerebroventricular administration of NMDA in freely moving rats. Maione, S., Vitagliano, S., Berrino, L., Lampa, E., Rossi, F. Neuropharmacology (1992) [Pubmed]
  17. Surgically reversible hypothalamic hypopituitarism due to aqueductal stenosis. Case report. Dempsey, R.J., Chandler, W.F., Sauder, S.E. J. Neurosurg. (1983) [Pubmed]
  18. The role of delta-opioid receptors in estrogen facilitation of lordosis behavior. Acosta-Martinez, M., Etgen, A.M. Behav. Brain Res. (2002) [Pubmed]
  19. Cyclic GMP may potentiate lordosis behaviour by progesterone receptor activation. Chu, H.P., Morales, J.C., Etgen, A.M. J. Neuroendocrinol. (1999) [Pubmed]
  20. Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge. Orikasa, C., Kondo, Y., Hayashi, S., McEwen, B.S., Sakuma, Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  21. The role of endogenous atrial natriuretic peptide in resting and stress-induced release of corticotropin, prolactin, growth hormone, and thyroid-stimulating hormone. Franci, C.R., Anselmo-Franci, J.A., McCann, S.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Uehara, Y., Shimizu, H., Ohtani, K., Sato, N., Mori, M. Diabetes (1998) [Pubmed]
  23. Role of anteroventral third ventricle and vasopressin in renal response to stress in borderline hypertensive rats. Hatton, D.C., Jones, S.Y., Johnson, A.K., DiBona, G.F. Hypertension (1991) [Pubmed]
  24. Some central mechanisms of thirst in the dog. Ramsay, D.J., Reid, I.A. J. Physiol. (Lond.) (1975) [Pubmed]
  25. Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. Guadaño-Ferraz, A., Escámez, M.J., Rausell, E., Bernal, J. J. Neurosci. (1999) [Pubmed]
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  27. The nyctohemeral rhythm of plasma prolactin: effects of ganglionectomy, pinealectomy, constant light, constant darkness or 6-OH-dopamine administration. Kizer, J.S., Zivin, J.A., Jacobowitz, D.M., Kopin, I.J. Endocrinology (1975) [Pubmed]
  28. Immunocytochemical colocalization of hypothalamic progestin receptors and tyrosine hydroxylase in steroid-treated monkeys. Kohama, S.G., Freesh, F., Bethea, C.L. Endocrinology (1992) [Pubmed]
  29. Progesterone increases dynorphin a concentrations in cerebrospinal fluid and preprodynorphin messenger ribonucleic Acid levels in a subset of dynorphin neurons in the sheep. Foradori, C.D., Goodman, R.L., Adams, V.L., Valent, M., Lehman, M.N. Endocrinology (2005) [Pubmed]
  30. Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts. Gibson, M.J., Krieger, D.T., Charlton, H.M., Zimmerman, E.A., Silverman, A.J., Perlow, M.J. Science (1984) [Pubmed]
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  42. Electron microscopic demonstration of a supraependymal cluster of neuronal cells and processes in the hamster third ventricle. Card, J.P., Mitchell, J.A. J. Comp. Neurol. (1978) [Pubmed]
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