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Gene Review:

Prl6a1 - prolactin family 6, subfamily a, member 1

Mus musculus

Synonyms: PLP-B, PRL-like protein B, Placental prolactin-like protein B, Prlpb, Prolactin-6A1

Müller, H. et al., Robertson, M.C. et al., Lin, J. et al.

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High impact information on Prl6a1

The open reading frame for mouse PLP-B encodes a protein of 230 residues; the putative mature glycoprotein of 201 amino acids is 66% identical to rat PLP-B [1].
The predicted rPL-I protein shares 41% amino acid identity with rPL-II precursor, 24% with rat prolactin-like protein A, 26% with rat prolactin-like protein B, and 31% with rat PRL [2].
In this report, we establish the presence of mouse homologues for two rat members, PRL-like protein-A (PLP-A) and PLP-B [3].
Perusal of the National Center for Biotechnology Information dbEST database resulted in the identification of several putative mouse PLP-A cDNAs and a single putative mouse PLP-B cDNA [3].

Anatomical context of Prl6a1

PLP-A was expressed in both trophoblast giant cells and spongiotrophoblast cells, whereas PLP-B was expressed in decidual and spongiotrophoblast cells [3].

References

Three new members of the mouse prolactin/growth hormone family are homologous to proteins expressed in the rat. Lin, J., Poole, J., Linzer, D.I. Endocrinology (1997) [Pubmed]
Molecular cloning and expression of rat placental lactogen-I complementary deoxyribonucleic acid. Robertson, M.C., Croze, F., Schroedter, I.C., Friesen, H.G. Endocrinology (1990) [Pubmed]
Homologues for prolactin-like proteins A and B are present in the mouse. Müller, H., Ishimura, R., Orwig, K.E., Liu, B., Soares, M.J. Biol. Reprod. (1998) [Pubmed]

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