Gene Review:
Prl - prolactin
Mus musculus
Synonyms:
AV290867, PRL, Prl1a1, Prolactin
- Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Bole-Feysot, C., Goffin, V., Edery, M., Binart, N., Kelly, P.A. Endocr. Rev. (1998)
- Prolactin gene-disruption arrests mammary gland development and retards T-antigen-induced tumor growth. Vomachka, A.J., Pratt, S.L., Lockefeer, J.A., Horseman, N.D. Oncogene (2000)
- Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation. Perrot-Applanat, M., Gualillo, O., Buteau, H., Edery, M., Kelly, P.A. J. Cell. Sci. (1997)
- The prolactin-deficient mouse has an unaltered metabolic phenotype. Lapensee, C.R., Horseman, N.D., Tso, P., Brandebourg, T.D., Hugo, E.R., Ben-Jonathan, N. Endocrinology (2006)
- Prolactin-like protein-f subfamily of placental hormones/cytokines: responsiveness to maternal hypoxia. Ho-Chen, J.K., Bustamante, J.J., Soares, M.J. Endocrinology (2007)
- Immune system development and function in prolactin receptor-deficient mice. Bouchard, B., Ormandy, C.J., Di Santo, J.P., Kelly, P.A. J. Immunol. (1999)
- Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic hypocretin, prolactin and 2',5'-oligoadenylate synthetase expression. Bohnet, S.G., Traynor, T.R., Majde, J.A., Kacsoh, B., Krueger, J.M. Brain Res. (2004)
- Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Schüssler, P., Uhr, M., Ising, M., Weikel, J.C., Schmid, D.A., Held, K., Mathias, S., Steiger, A. Psychoneuroendocrinology (2006)
- Associated effects of bromocriptine on neoplastic progression of mouse mammary preneoplastic hyperplastic alveolar nodule line C4 and on hyperplastic alveolar nodule-infiltrating and splenic lymphocyte function. Tsai, S.J., Loeffler, D.A., Heppner, G.H. Cancer Res. (1992)
- Secreted mouse prolactin (PRL) and stored ovine PRL. I. Biochemical characterization, isolation, and purification of their electrophoretic isoforms. Haro, L.S., Talamantes, F.J. Endocrinology (1985)
- Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Teglund, S., McKay, C., Schuetz, E., van Deursen, J.M., Stravopodis, D., Wang, D., Brown, M., Bodner, S., Grosveld, G., Ihle, J.N. Cell (1998)
- Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Dollé, P., Castrillo, J.L., Theill, L.E., Deerinck, T., Ellisman, M., Karin, M. Cell (1990)
- Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue. Ossowski, L., Biegel, D., Reich, E. Cell (1979)
- IRS-2 pathways integrate female reproduction and energy homeostasis. Burks, D.J., Font de Mora, J., Schubert, M., Withers, D.J., Myers, M.G., Towery, H.H., Altamuro, S.L., Flint, C.L., White, M.F. Nature (2000)
- Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Heaney, A.P., Horwitz, G.A., Wang, Z., Singson, R., Melmed, S. Nat. Med. (1999)
- Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants. Campbell, G.S., Argetsinger, L.S., Ihle, J.N., Kelly, P.A., Rillema, J.A., Carter-Su, C. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Transgenic mice overexpressing the prolactin gene develop dramatic enlargement of the prostate gland. Wennbo, H., Kindblom, J., Isaksson, O.G., Törnell, J. Endocrinology (1997)
- Evaluation of prolactin-like activity produced by concanavalin-A stimulated mouse splenocytes. Gala, R.R., Rillema, J.A. Life Sci. (1995)
- Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin. Kindblom, J., Dillner, K., Sahlin, L., Robertson, F., Ormandy, C., Törnell, J., Wennbo, H. Endocrinology (2003)
- Prolactin-mediated gene activation in mammary epithelial cells. Groner, B., Gouilleux, F. Curr. Opin. Genet. Dev. (1995)
- A prolactin family paralog regulates reproductive adaptations to a physiological stressor. Ain, R., Dai, G., Dunmore, J.H., Godwin, A.R., Soares, M.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. Aoki, N., Matsuda, T. J. Biol. Chem. (2000)
- Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia. Akhtar, N., Streuli, C.H. J. Cell Biol. (2006)
- Function of the homeodomain protein GHF1 in pituitary cell proliferation. Castrillo, J.L., Theill, L.E., Karin, M. Science (1991)
- Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase. Yamauchi, T., Kaburagi, Y., Ueki, K., Tsuji, Y., Stark, G.R., Kerr, I.M., Tsushima, T., Akanuma, Y., Komuro, I., Tobe, K., Yazaki, Y., Kadowaki, T. J. Biol. Chem. (1998)
- Immunocytochemical effects of thyroxine stimulation on the adenohypophysis of dwarf (dw) mutant mice. Wilson, D.B., Wyatt, D.P. Cell Tissue Res. (1993)
- Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms. Schuff, K.G., Hentges, S.T., Kelly, M.A., Binart, N., Kelly, P.A., Iuvone, P.M., Asa, S.L., Low, M.J. J. Clin. Invest. (2002)
- Identification of JAK protein tyrosine kinases as signaling molecules for prolactin. Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells. Dusanter-Fourt, I., Muller, O., Ziemiecki, A., Mayeux, P., Drucker, B., Djiane, J., Wilks, A., Harpur, A.G., Fischer, S., Gisselbrecht, S. EMBO J. (1994)
- Proliferin, a prolactin/growth hormone-like peptide represses myogenic-specific transcription by the suppression of an essential serum response factor-like DNA-binding activity. Muscat, G.E., Gobius, K., Emery, J. Mol. Endocrinol. (1991)
- Prolactin concurrently activates src-PLD and JAK/Stat signaling pathways to induce proliferation while promoting differentiation in embryonic astrocytes. Mangoura, D., Pelletiere, C., Leung, S., Sakellaridis, N., Wang, D.X. Int. J. Dev. Neurosci. (2000)
- Characterization of plasma and intracellular membrane prolactin receptor in lactating mouse mammary cells. Sakai, S., Mizoguchi, Y., Kim, J.Y. Endocr. J. (1994)
- Prolactin-dependent activation of a tyrosine phosphorylated DNA binding factor in mouse mammary epithelial cells. Welte, T., Garimorth, K., Philipp, S., Doppler, W. Mol. Endocrinol. (1994)
- Regulation of estrogen receptor activation of the prolactin enhancer/promoter by antagonistic activation function-2-interacting proteins. Schaufele, F. Mol. Endocrinol. (1999)
- Stat5a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity. Beuvink, I., Hess, D., Flotow, H., Hofsteenge, J., Groner, B., Hynes, N.E. J. Biol. Chem. (2000)
- Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Liu, X., Robinson, G.W., Gouilleux, F., Groner, B., Hennighausen, L. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells. Srivastava, S., Matsuda, M., Hou, Z., Bailey, J.P., Kitazawa, R., Herbst, M.P., Horseman, N.D. J. Biol. Chem. (2003)
- Janus kinase 2 (JAK2) regulates prolactin-mediated chloride transport in mouse mammary epithelial cells through tyrosine phosphorylation of Na+-K+-2Cl- cotransporter. Selvaraj, N.G., Omi, E., Gibori, G., Rao, M.C. Mol. Endocrinol. (2000)
- Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Hovey, R.C., Harris, J., Hadsell, D.L., Lee, A.V., Ormandy, C.J., Vonderhaar, B.K. Mol. Endocrinol. (2003)
- Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect. Halperin, J., Devi, S.Y., Elizur, S., Stocco, C., Shehu, A., Rebourcet, D., Unterman, T.G., Leslie, N.D., Le, J., Binart, N., Gibori, G. Mol. Endocrinol. (2008)
- Regulation of mammary differentiation by extracellular matrix involves protein-tyrosine phosphatases. Edwards, G.M., Wilford, F.H., Liu, X., Hennighausen, L., Djiane, J., Streuli, C.H. J. Biol. Chem. (1998)
- Progesterone Receptor Repression of Prolactin/Signal Transducer and Activator of Transcription 5-Mediated Transcription of the {beta}-Casein Gene in Mammary Epithelial Cells. Buser, A.C., Gass-Handel, E.K., Wyszomierski, S.L., Doppler, W., Leonhardt, S.A., Schaack, J., Rosen, J.M., Watkin, H., Anderson, S.M., Edwards, D.P. Mol. Endocrinol. (2007)
- The prolactin gene is expressed in the mouse kidney. Sakai, Y., Hiraoka, Y., Ogawa, M., Takeuchi, Y., Aiso, S. Kidney Int. (1999)
- Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) is induced by prolactin and suppressed by progesterone in mammary epithelium. Hou, Z., Bailey, J.P., Vomachka, A.J., Matsuda, M., Lockefeer, J.A., Horseman, N.D. Endocrinology (2000)