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Gene Review: 

unc-42  -  Protein UNC-42

Caenorhabditis elegans

 
 
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High impact information on unc-42

  • The C. elegans homeodomain gene unc-42 regulates chemosensory and glutamate receptor expression [1].
  • The AVA, AVD and AVE interneurons and RME and RMD motor neurons of unc-42 mutants similarly fail to express the GLR-1 glutamate receptor [1].
  • These observations support a combinatorial role for fax-1 and unc-42 in specifying AVA and AVE identity [2].
  • The unc-42 homeobox gene also regulates AVA and AVE identity; however, unc-42 mutants display the complementary phenotype: NMDA receptor subunit expression is normal, but some non-NMDA glutamate receptor subunits are not expressed [2].
  • The mRNA is 1.5 kb in size and is formed by trans-splicing to SL1, a common 5' RNA segment. odc-1 maps to the middle of LG V, between dpy-11 and unc-42 and near a breakpoint of the nDf32 deficiency strain [3].

References

  1. The C. elegans homeodomain gene unc-42 regulates chemosensory and glutamate receptor expression. Baran, R., Aronoff, R., Garriga, G. Development (1999) [Pubmed]
  2. The C. elegans nuclear receptor gene fax-1 and homeobox gene unc-42 coordinate interneuron identity by regulating the expression of glutamate receptor subunits and other neuron-specific genes. Wightman, B., Ebert, B., Carmean, N., Weber, K., Clever, S. Dev. Biol. (2005) [Pubmed]
  3. The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis. Macrae, M., Plasterk, R.H., Coffino, P. Genetics (1995) [Pubmed]
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