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Gene Review

odc-1  -  Protein ODC-1

Caenorhabditis elegans

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High impact information on odc-1

  • We now show that when ODC-deficient worms are transferred to polyamine-free medium, they show a strong phenotype. odc-1 worms have two different fates, depending upon the developmental stage at which polyamines are removed [1].
  • Supplementing deficient medium with the polyamine spermidine allows ODC-deficient worms to develop as on complex medium [1].
  • Ornithine decarboxylase (ODC) catalyses the conversion of ornithine to putrescine, an obligate precursor to the polyamines spermidine and spermine [1].
  • Together, these findings suggest that ODC activity is most critically required during oogenesis and embryogenesis and, furthermore, that exogenous polyamines can override the requirement for ODC activity [1].
  • The mRNA is 1.5 kb in size and is formed by trans-splicing to SL1, a common 5' RNA segment. odc-1 maps to the middle of LG V, between dpy-11 and unc-42 and near a breakpoint of the nDf32 deficiency strain [2].

Biological context of odc-1


Associations of odc-1 with chemical compounds


Other interactions of odc-1


Analytical, diagnostic and therapeutic context of odc-1

  • Molecular cloning and characterization of ornithine decarboxylase cDNA of the nematode Panagrellus redivivus [3].
  • In a PCR with degenerate primers encoding highly conserved amino acids within ornithine decarboxylases (ODCs) of several organisms, a fragment of the ODC gene of the free-living nematode Panagrellus redivivus was isolated [3].


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