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Gene Review:

Rad17 - RAD17 homolog (S. pombe)

Mus musculus

Synonyms: 9430035O09Rik, Cell cycle checkpoint protein RAD17, MmRad24

Post, S. et al., Bao, S. et al., Hammond, E.M. et al.

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Disease relevance of Rad17

Here we show that like aphidicolin and hydroxyurea, hypoxia induces phosphorylation of Nbs1 at serine 343 and Rad17 serine 645 [1].

High impact information on Rad17

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage [2].

Analytical, diagnostic and therapeutic context of Rad17

Confocal microscopy revealed that the green fluorescent protein-tagged MmRad24 protein is localized to the nucleus in living cells [3].

References

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Hammond, E.M., Green, S.L., Giaccia, A.J. Mutat. Res. (2003) [Pubmed]
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Post, S., Weng, Y.C., Cimprich, K., Chen, L.B., Xu, Y., Lee, E.Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. Bao, S., Shen, X., Shen, K., Liu, Y., Wang, X.F. Cell Growth Differ. (1998) [Pubmed]

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