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Gene Review

RAD17  -  RAD17 homolog (S. pombe)

Homo sapiens

Synonyms: CCYC, Cell cycle checkpoint protein RAD17, HRAD17, R24L, RAD17SP, ...
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Disease relevance of RAD17


High impact information on RAD17


Biological context of RAD17


Anatomical context of RAD17


Associations of RAD17 with chemical compounds


Physical interactions of RAD17


Enzymatic interactions of RAD17

  • Here we demonstrate that ATR but not ATM phosphorylates the human Rad17 (hRad17) checkpoint protein on Ser(635) and Ser(645) in vitro [12].

Regulatory relationships of RAD17


Other interactions of RAD17

  • The chromatin associations of Rad17 and ATR are largely independent, which suggests that they localize to DNA damage independently [20].
  • Rad17-RFC binds to nicked circular, gapped, and primed DNA and recruits the 9-1-1 complex in an ATP-dependent manner [21].
  • Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling [8].
  • An enhanced colocalization of Rad17 and PCNA in late S phase after hydroxyurea treatment was observed [14].
  • To begin to understand the protein-protein interactions of the human checkpoint machinery, we have used the yeast two-hybrid system to examine potential interactions between Hrad1, Hrad9, and Hrad17 [22].

Analytical, diagnostic and therapeutic context of RAD17


  1. Genomic instability and endoreduplication triggered by RAD17 deletion. Wang, X., Zou, L., Zheng, H., Wei, Q., Elledge, S.J., Li, L. Genes Dev. (2003) [Pubmed]
  2. Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. von Deimling, F., Scharf, J.M., Liehr, T., Rothe, M., Kelter, A.R., Albers, P., Dietrich, W.F., Kunkel, L.M., Wernert, N., Wirth, B. Hum. Genet. (1999) [Pubmed]
  3. 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. Luciani, M.G., Campregher, C., Fortune, J.M., Kunkel, T.A., Gasche, C. Gastroenterology (2007) [Pubmed]
  4. hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation. Li, L., Peterson, C.A., Kanter-Smoler, G., Wei, Y.F., Ramagli, L.S., Sunnerhagen, P., Siciliano, M.J., Legerski, R.J. Oncogene (1999) [Pubmed]
  5. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Bao, S., Tibbetts, R.S., Brumbaugh, K.M., Fang, Y., Richardson, D.A., Ali, A., Chen, S.M., Abraham, R.T., Wang, X.F. Nature (2001) [Pubmed]
  6. Multiple alternative splicing forms of human RAD17 and their differential response to ionizing radiation. Chen, M.S., Higashikubo, R., Laszlo, A., Roti Roti, J. Gene (2001) [Pubmed]
  7. The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. Post, S.M., Tomkinson, A.E., Lee, E.Y. Nucleic Acids Res. (2003) [Pubmed]
  8. Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. Tsao, C.C., Geisen, C., Abraham, R.T. EMBO J. (2004) [Pubmed]
  9. Inhibition of Transforming Growth Factor-{beta}1 Signaling Attenuates Ataxia Telangiectasia Mutated Activity in Response to Genotoxic Stress. Kirshner, J., Jobling, M.F., Pajares, M.J., Ravani, S.A., Glick, A.B., Lavin, M.J., Koslov, S., Shiloh, Y., Barcellos-Hoff, M.H. Cancer Res. (2006) [Pubmed]
  10. Determination of the genotype of a panel of human tumor cell lines for the human homologues of yeast cell cycle checkpoint control genes: identification of cell lines carrying homoallelic missense base substitutions. Ejima, Y., Yang, L. Somat. Cell Mol. Genet. (1999) [Pubmed]
  11. Overexpression of Hrad17 gene in non-small cell lung cancers correlated with lymph node metastasis. Sasaki, H., Chen, L.B., Auclair, D., Moriyama, S., Kaji, M., Fukai, I., Kiriyama, M., Yamakawa, Y., Fujii, Y. Lung Cancer (2001) [Pubmed]
  12. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Post, S., Weng, Y.C., Cimprich, K., Chen, L.B., Xu, Y., Lee, E.Y. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  13. Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. Griffith, J.D., Lindsey-Boltz, L.A., Sancar, A. J. Biol. Chem. (2002) [Pubmed]
  14. Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block. Dahm, K., Hübscher, U. Oncogene (2002) [Pubmed]
  15. Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body. Nabetani, A., Yokoyama, O., Ishikawa, F. J. Biol. Chem. (2004) [Pubmed]
  16. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K.E., Hittelman, W.N., Elledge, S.J., Li, L. Mol. Cell (2006) [Pubmed]
  17. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Shiotani, B., Kobayashi, M., Watanabe, M., Yamamoto, K., Sugimura, T., Wakabayashi, K. Mol. Cancer Res. (2006) [Pubmed]
  18. Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. Bluyssen, H.A., Naus, N.C., van Os, R.I., Jaspers, I., Hoeijmakers, J.H., de Klein, A. Genomics (1999) [Pubmed]
  19. Hrad17 expression in thymoma. Sasaki, H., Kobayashi, Y., Yukiue, H., Yano, M., Kaji, M., Fukai, I., Kiriyama, M., Yamakawa, Y., Fujii, Y. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi. (2003) [Pubmed]
  20. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Zou, L., Cortez, D., Elledge, S.J. Genes Dev. (2002) [Pubmed]
  21. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Bermudez, V.P., Lindsey-Boltz, L.A., Cesare, A.J., Maniwa, Y., Griffith, J.D., Hurwitz, J., Sancar, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  22. Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene. Parker, A.E., Van de Weyer, I., Laus, M.C., Verhasselt, P., Luyten, W.H. J. Biol. Chem. (1998) [Pubmed]
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